Peter C. Lucas, MD, PhD

  • Professor and Vice Chair of Pathology and Professor of Pediatrics
  • Director, Center of Translational Pathology, UPMC Hillman Cancer Center
  • Director of Pathology, NSABP/NRG Oncology

Administrative Assistant: Carla Clarke

Professional and Scientific Society Memberships

  • Associate Member Sigma Xi 1987 
  • Member, American Society for the Advancement of Science 1995 - 2001 
  • Junior Member, College of American Pathologists 1997 - 2004 
  • Junior Member, United States and Canadian Academy of Pathology 2001 - 2004 
  • Member, Central Society for Clinical Research (CSCR) 2008 - 2010 
  • Member, Michigan Society of Pathologists 2009 - 2011 
  • Mid-Career Fellow, College of American Pathologists (CAP) 2009 - 2012 
  • Member, Association of Pathology Chairs (APC) 2009 - 2012 
  • Full Member, United States and Canadian Academy of Pathology (USCAP) 2010 - 2013 
  • Member, American Society for Investigative Pathology (ASIP) 2011 – present  
  • Member, Association for Molecular Pathology (AMP) 2012 – present 
  • Member, American Society for Clinical Investigation (ASCI) 2014 – present 
  • Member, American Association for Cancer Research (AACR) 2016 – present  
  • Member, American Society of Clinical Oncology (ASCO) 2016 – present  

Education & Training

  • BA, Carleton College, 1987
  • PhD, Vanderbilt University, 1992
  • MD, Vanderbilt University, 1996
  • Research Fellow, Vanderbilt University, 1994
  • Resident, University of Michigan, 1998
  • Clinical Fellow, University of Michigan, 1999
  • Research Fellow, University of Michigan, 2001

Selected Publications

Durant PAC, Lucas PC, and Yaksh TL (1987) Micturition in the unanesthetized rat.  II. Central versus peripheral pharmacology of the adrenergic system.  J. Pharmacology and Exp. Ther., 245:426-435. 

O'Brien RM, Lucas PC, Forest CD, Magnuson MA, and Granner DK (1990) Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription.  Science, 249:533-537. 

Forest CD, O'Brien RM, Lucas PC, Magnuson MA, and Granner DK (1990) Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin.  Use of the stable transfection approach to locate an insulin responsive sequence.  Mol. Endocrinol., 4:1302-1310. 

Lucas PC, O'Brien RM, Mitchell JA, Davis CM, Imai E, Forman BM, Samuels HH, and Granner, DK (1991) A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene.  Proc. Natl. Acad. Sci. USA, 88:2184-2188. 

Lucas PC, Forman BM, Samuels HH, and Granner, DK (1991) Specificity of a retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter: Consequences of both retinoic acid and thyroid hormone receptor binding.  Mol. Cell. Biol., 11:5164-5170. 

Ong DE, Lucas PC, Kakkad B, and Quick TC (1991) Ontogeny of two vitamin A-metabolizing enzymes and two retinol-binding proteins present in the small intestine of the rat.  J. Lipid Res., 32:1521-1527. 

Granner DK, O'Brien RM, Imai E, Forest CD, Mitchell JA, and Lucas PC (1991) Complex hormone response unit regulating transcription of the phosphoenolpyruvate carboxykinase gene:  From metabolic pathways to molecular biology.  Rec. Prog. Horm. Res., 47:319-348. 

O'Brien RM, Lucas PC, Yamasaki T, Bonovich MT, Forest CD, and Granner DK (1992) Insulin and phorbol esters act through the same DNA element to inhibit phosphoenolpyruvate carboxykinase gene transcription.  Biochem. Soc. Trans., 20:686-690. 

Lucas PC and Granner DK (1992) Hormone response domains in gene transcription.  Ann. Rev. Biochem., 61:1131-1173. 

Hall RK, Scott DK, Noisin EL, Lucas PC, and Granner DK (1992) Activation of the PEPCK retinoic acid response element is dependent on a retinoic acid receptor/coregulator complex.  Mol. Cell. Biol., 12:5527-5535. 

Full Publication List via NIH PubMed

Research Interests

Inflammation, Cancer Biology, and Targeted Cancer Therapeutics

Research Grants

R01 CA207196  (Lucas/McAllister-Lucas, PIs)02/01/18 – 01/31/231.8 calendar months NIH (NCI)$348,506 annual directs(15% effort) Role: Co-PI 

R01 HL082914-11 (Lucas/McAllister-Lucas, PIs)02/01/13 – 01/31/191.8 calendar months NIH (NHLBI)No cost extension(15% effort) Role:  co-PI

U24 CA196067 (Jordan/Lucas/Ramirez, PIs)04/01/17 – 03/31/201.1 calendar months NIH (NCI)$2,158,763 Total costs(9% effort) Role: Co-PI