Radhika H. Muzumdar, MD
- Division Director, Endocrinology and Professor of Pediatrics and Cell Biology
Muzumdar completed medical school at Kilpauk Medical College, Chennai and residency in Topiwala National Medical College in Mumbai, India. She completed her pediatric residency at State University of New York, and fellowship in Pediatric Endocrinology at Children’s Hospital at Montefiore, Albert Einstein College of Medicine. She joined the faculty at Children’s Hospital of Montefiore until her recruitment to Pitt Pediatrics in January 2014 as Division Director of Endocrinology.
Her clinical interests include care of children with diabetes, growth and adrenal disorders, thyroid problems and disorders of puberty. Her research is focused on GH, insulin-like growth factors and their binding partners, and a novel mitochondria-associated peptide called humanin on glucose homeostasis, energy metabolism, cardiovascular health and aging. Her lab is also studying the link between Absent in Melanoma 2 (AIM 2) and obesity, bone health and life span. In addition to the NIH, Muzumdar has received grant support from multiple funding agencies, including the Pediatric Endocrine Society (PES), American Federation for Aging Research (AFAR), Beck Foundation, and Endocrine Fellows Foundation and Children’s Hospital Foundation.
Muzumdar serves on several national and international study sections, including the NIH, AFAR research council, Binational Israel foundation, Israeli Science Foundation, Marsden Fund (New Zealand) and Wellcome Trust UK. She served as standing member on the NIA/ASG study section and is on AFAR’s National Scientific Advisory Council. Muzumdar is the principal investigator of the Research Training in Pediatric Endocrinology program (T32). She is an active member of the PES. She is chair of the National Mentoring initiative of PES and Immediate past Chair of the Research advisory council of PES. She is the president of the American Diabetes Association board of Western Pennsylvania.
Professional and Scientific Society Memberships
- Pediatric Endocrine Society (formerly LWPES), 2000–Present
- Society for Pediatric Research, 2006–Present
- American Diabetes Association, 2009–Present
- Endocrine Society, 2011–Present
- American Pediatric Society, 2014-Present
- Board Member, ADA of Western Pennsylvania, 2019-Present
Education & Training
- MBBS, Kilpauk Medical College, 1988
- DCH, College of Physicians and Surgeons, 1992
- MD, T.N. Medical College, 1993
- Internship, Royapettah Hospital, 1988-1989
- Residency in Pediatrics, BYL Nair Hospital, 1990-1993
- Residency in Pediatrics, State University of New York at Brooklyn, 1995-1996
- Fellowship, Montefiore Medical Center, 2000-2003
harathi SS PhD, Zhang Y, Gong Z, Muzumdar R, Goetzman E. Role of Mitochondrial Acyl-CoA Dehydrogenases in the Metabolism of Dicarboxylic Fatty Acids, Accepted at BBRC, May 2020
Cerqueira DM, Bodnar AJ, Hemker SL, Ortiz DM, Oladipupo FO, Mukherjee E, Gong Z, Muzumdar R, Sims-Lucas S and Ho J. In utero exposure to maternal diabetes impairs nephron progenitor differentiation. Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1318-F1330. doi: 10.1152/ajprenal.00204.2019. Epub 2019 Sep 11. PMID: 3150901
Gong Z, Zhang X, Su K, Jiang R, Sun Z, Chen W, Forno E, Goetzman E S, Wang J, Dong HH, Dutta P , Muzumdar RH. Deficiency in AIM2 induces inflammation and adipogenesis in white adipose tissue leading to obesity and insulin resistance, Diabetologia. 2019 Dec;62(12):2325-2339. doi: 10.1007/s00125-019-04983-x. Epub 2019 Sep 11. PMID: 31511929
Feeley C A, Sereika S M, Chasens E R, Siminerio L, Charron-Prochownik D, Muzumdar R H, Viswanathan P. Sleep in Parental Caregivers and Children With Type 1 Diabetes. Journal of School Nursing Published on 01 Jan 2019, doi: 10.1177/1059840519865942, PMID: 31366301
Wang Y, Cobanoglu M, Li J, Hidvegi T, Hale P, EwingM, Chu A, Gong Z, Muzumdar R, Pak S, Silverman G, Bahar I, Perlmutter D. Genome-wide RNAi screening combined with computational systems pharmacology identifies glibenclamide as a potent therapeutic candidate for liver disease due to α-1-antitrypsin deficiency. PLoS One. 2019 Jan 23;14(1):e0209748. doi: 10.1371/journal.pone.0209748. eCollection 2019. PMID: 30673724
Robinson KM, Ramanan K, Clay ME, McHugh KJ, Pilewski MJ, Nickolich KL, Corey C, Shiva S, Wang J, Muzumdar R, Alcorn JF. The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice. JCI Insight. 2018 Apr 5;3(7). pii: 97470. doi: 10.1172/jci.insight.97470. [Epub ahead of print]. PMID: 29618653.
Forno E, Han Y, Libman I, Muzumdar R, Celedón J. Adiposity and asthma in a nationwide study of children and adults in the United States. Ann Am Thorac Soc. 2018 Mar;15(3):322-330. doi: 10.1513/AnnalsATS.201709-723OC. PMID: 29144884.
Gong Z, Tasset I, Diaz A, Anguiano J, Tas E, Cui L, Kuliawat R, Kuhn B, Cuervo AM and Muzumdar R. Role of humanin in chaperone mediated-autophagy. J Cell Biol. 2018 Feb 5;217(2):635-647. doi: 10.1083/jcb.201606095. Epub 2017 Nov 29. PMID: 29187525.
Cheng X, Yamauchi J, Lee S, Zhang T, Gong Z, Muzumdar R, Qu S, Dong HH. APOC3 Protein Is Not a Predisposing Factor for Fat-induced Nonalcoholic Fatty Liver Disease in Mice. J Biol Chem. 2017 Mar 3;292(9):3692-3705. doi: 10.1074/jbc.M116.765917. PMID: 28115523
Bloom K, Mohsen A-W, Karunanidhi A, El Demellawy D, Reyes-Mugica M, Wang, Y, Gonzalez L, Otsuba C, Tobita K, Bertera S, Muzumdar R, Gong Z, Tas E, Chen, J, Bennett M, Hoppel C, Vockley J. Investigating the link of ACAD10 deficiency to type 2 diabetes mellitus. J Inherit Metab Dis. J Inherit Metab Dis. 2018 Jan;41(1):49-57. doi: 10.1007/s10545-017-0013-y. Epub 2017 Jan 24.PMID: 28120165.
NIH T32 Endocrinology training grant, 2014-Present
Department of Role of Human in in Age Related Diseases, 2014-unrestricted, Department of Pediatrics University of Pittsburgh, $1,400,000
AD2015-79344, Humanin and cytoprotection, 2015-Present, The Pittsburgh Foundation, John and Frances Beck Family Foundation, $16,500
2T32DK007729-16, Research Training in Pediatric Endocrinology, 2016-2021, NIH/NIDDKD, $199,547.00
NIH 1R01 DK109907, Metabolism of Short Chain Acyl-CoA and Its Deficiency, 2016-2021, $11,180.00
CHP Foundation, High Fidelity Wraparound Type 1 diabetes, 2018-2021, $500,000.00
Cochrane Weber, Role of Aim 2 in metabolism, 2018-2021, $39,000.00
NIH 1R56HL137711, Role of Humanin in Cardioprotection, 2018-2020, $684,468.00
NIH R-01, Myeloid FoxO1 in Insulin Action and Glucose Metabolism, 2019-2024, $11,678.00