Selma Feldman Witchel, MD

  • Professor of Pediatrics
  • Director, Pediatric Endocrinology Fellowship Program

Selma Feldman Witchel, MD is a Professor of Pediatrics at the University of Pittsburgh School of Medicine. Witchel is the Program Director for the pediatric endocrinology fellowship training program at UPMC Children's Hospital of Pittsburgh. She chairs the Differences in Sex Development Committee at the UPMC Children's Hospital of Pittsburgh. She received her Bachelor of Arts degree from Oberlin College and her medical degree at the University of Pittsburgh. She completed her pediatric residency at the Children’s Hospital Medical Center, University of Cincinnati and her pediatric endocrinology fellowship at the Children’s Hospital of Pittsburgh, University of Pittsburgh. She is primarily interested in the physiology and genetics of the hypothalamic-pituitary-gonadal (HPG) and the hypothalamic-pituitary-adrenal (HPA) axes. Her interests extend to the care of patients with differences in sex development and the care of transgender youth. Her research elucidated the concept of the “manifesting heterozygote” in patients with disorders of steroidogenesis. She was actively involved in the global enterprise that culminated in the 2018 publication of the “Evidence Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.” She has published over 200 articles, reviews, and chapters. Witchel has trained over 50 fellows.

Professional and Scientific Society Memberships

  • American Academy of Pediatrics (Fellow), 1984-Present
  • American Diabetes Association, 1987-Present
  • Lawson Wilkins Pediatric Endocrine Society (PES), 1989-Present
  • Endocrine Society, 1991-Present
  • Society for Pediatric Research, 1995-Present
  • American Pediatric Society, 1995-Present
  • Androgen Excess-PCOS Society, 2003-Present
  • European Society of Pediatric Endocrinology, 2014-Present

Education & Training

  • BA, Biology, Oberlin College, 1974
  • MD, University of Pittsburgh School of Medicine, 1978
  • Internship, Children's Hospital Medical Center, 1978-1979
  • Residency in Pediatrics, Children's Hospital Medical Center, 1979-1981
  • Fellowship in Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh, 1981-1983

Selected Publications

Witchel SF, Lee PA, Suda-Hartman M, Trucco M, Hoffman EP. Evidence for a heterozygote advantage in congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Clin Endocrinol Metab 1997;82:2097-2101.  PMID 9215278


Moran C, Azziz R, Weintrob N, Witchel SF, Rohmer V, Dewailly D, Marcondes JA, Pugeat M, Speiser PW, Pignatelli D, Mendonca BB, Bachega TA, Escobar-Morreale HF, Carmina E, Fruzzetti F, Kelestimur F. Reproductive Outcome of Women with 21-Hydroxylase Deficient Nonclassical Adrenal Hyperplasia. J Clin Endocrinol Metab. 2006;91(9):3451-6.  PMID 16822826


Ibáñez L, Oberfield SE, Witchel SF, Auchus RJ, Chang RJ, Codner E, Dabadghao P, Darendeliler F, Elbarbary NS, Gambineri A, Garcia Rudaz C, Hoeger KM, López-Bermejo A, Ong K, Peña AS, Reinehr T, Santoro N, Tena-Sempere M, Tao R, Yildiz BO, Alkhayyat H, Deeb A, Joel D, Horikawa R, de Zegher F, Lee PA. An international consortium update: Pathophysiology, diagnosis, and treatment of polycystic ovarian syndrome in adolescence. Horm Res Pædiatric 2017 DOI:10.1159/000479371. Horm Res Paediatr. 2017 Nov 13;Vol.(6):307-331. doi: 10.1159/000479371. [Epub ahead of print] PMID: 29156452


Portnoi MF, Dumargne MC, Rojo S, Witchel SF, Duncan AJ, Eozenou C, Bignon-Topalovic J, Yatsenko SA, Rajkovic A, Reyes-Mugica M, Almstrup K, Fusee L, Srivastava Y, Chantot-Bastaraud S, Hyon C, Louis-Sylvestre C, Validire P, de Malleray Pichard C, Ravel C, Christin-Maitre S, Brauner R, Rossetti R, Persani L, Charreau EH, Dain L, Chiauzzi VA, Mazen I, Rouba H, Schluth-Bolard C, MacGowan S, McLean WHI, Patin E, Rajpert-De Meyts E, Jauch R, Achermann JC, Siffroi JP, McElreavey K, Bashamboo A. Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies. Hum Mol Genet. 2018 Jan 24. doi: 10.1093/hmg/ddy037. PMID: 29373757


Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, Piltonen T, Norman RJ; International PCOS Network. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 2018 Jul 12. pii: S0015-0282(18)30400-X. doi: 10.1016/j.fertnstert.2018.05.004. [Epub ahead of print] PMID:30033227. Published simultaneously in Clin Endocrinol 2018;89(3):251-268. doi: 10.1111/cen.13795. Epub 2018 Jul 19; PMID: 30024653 and in Hum Reprod 2018;33(9):1602-1618. doi: 10.1093/humrep/dey256; PMID: 30052961


Rothenberg SS, Witchel SF, Menke MN. Oocyte Cryopreservation in an Adolescent Transgender Male on a GnRH Agonist. New England Journal of Medicine 2019;380(9):886-887. PMID:30811918


Eozenou C, Gonen N, Touzon MS, Jorgensen A, Yatsenko SA, Fusee F, Kamel AK, Gellen B, Guercio G, Singh P, Witchel S, Berman AJ,  Mainpal R, Totonchi M,  Meybodi AM, Askari M, Merel T, Bignon-Topalovic J, Migale R, Costanzo M, Marino R, Ramirez P, Garrido NP, Berensztein E, Mekkawy MK, Schimenti JC, Bertalan R, Mazen I, McElreavey K, Belgorosky A, Lovell-Badge R, Rajkovic A, Bashamboo A. Testis formation in XX individuals resulting from novel pathogenic variants in Wilms’ tumor 1 (WT1) gene. Proc Natl Acad Sci U S A. 2020;117:13680-13688. PMID: 32493750


Witchel SF and Plant TM. Intertwined reproductive endocrinology: Puberty and PCOS. Current Opin Endocrine and Metabolic Research 2020 Oct;14:127-136. PMID: 33102929


Torres OA, Miller E, Witchel SF. Quality Improvement in the Evaluation and Diagnosis of Polycystic Ovary Syndrome in Adolescent Girls. J Pediatr Adolesc Gynecol. 2021 Mar 6:S1083-3188(21)00150-9. doi: 10.1016/j.jpag.2021.03.001. Epub ahead of print. PMID: 33689916.


Witchel SF. Plant TM. Neurobiology of Puberty and its Disorders. In Swaab D, Lucassen P,Kreier Ruud Buijs F. Salehi A (eds)., Handbook of Clinical Neurology, Volume 181, Elsevier, Amsterdam, 2021 (in press).



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Academic and Research Interests

  • Polycystic Ovary Syndrome
  • Congenital Adrenal Hyperplasia
  • Puberty
  • Differences in Sex Development
  • Transgender Youth
  • Glucocorticoid Action

Research Grants

R01DK069950-12, Molecular Mechanisms of Adrenarche, 2017-2020, NIH, $61,088