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Sivakama S. Bharathi, PhD
- Senior Research Technician
Dr. Bharathi completed a PhD in Chemistry at the Indian Institute of Technology, Madras. She joined the University of Pittsburgh in 2009, working first in the Department of Neurology before joining the Goetzman Lab in the Department of Pediatrics in 2010. She is currently a Senior Research Tech in the lab, focusing on energy metabolism and metabolic disorders.
Professional and Scientific Society Memberships
- American Society for Nephrology
Selected Publications
Phenylalanine hydroxylase deficient phenylketonuria comparative metabolomics identifies energy pathway disruption and oxidative stress. Dobrowolski SF, Phua YL, Sudano C, Spridik K, Zinn PO, Wang Y, Bharathi S, Vockley J, Goetzman E. Mol Genet Metab. 2021 Apr 7:S1096-7192(21)00686-7. doi: 10.1016/j.ymgme.2021.04.002. PMID: 33846068
Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency. Pereyra AS, Harris KL, Soepriatna AH, Waterbury QA, Bharathi SS, Zhang Y, Fisher-Wellman KH, Goergen CJ, Goetzman ES, Ellis JM. J Lipid Res. 2021 Mar 20;62:100069. doi: 10.1016/j.jlr.2021.100069. PMID: 33757734
Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice. Goetzman ES, Bharathi SS, Zhang Y, Zhao XJ, Dobrowolski SF, Peasley K, Sims-Lucas S, Monga SP. Sci Rep. 2020 Oct 27;10(1):18367. doi: 10.1038/s41598-020-75615-3. PMID: 33110171
The common K333Q polymorphism in long-chain acyl-CoA dehydrogenase (LCAD) reduces enzyme stability and function. Beck ME, Zhang Y, Bharathi SS, Kosmider B, Bahmed K, Dahmer MK, Nogee LM, Goetzman ES. Mol Genet Metab. 2020 Sep-Oct;131(1-2):83-89. doi: 10.1016/j.ymgme.2020.04.005. PMID: 32389575
Role of mitochondrial acyl-CoA dehydrogenases in the metabolism of dicarboxylic fatty acids. Bharathi SS, Zhang Y, Gong Z, Muzumdar R, Goetzman ES. Biochem Biophys Res Commun. 2020 Jun 18;527(1):162-166. doi: 10.1016/j.bbrc.2020.04.105. PMID: 32446361
Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI. Chiba T, Peasley KD, Cargill KR, Maringer KV, Bharathi SS, Mukherjee E, Zhang Y, Holtz A, Basisty N, Yagobian SD, Schilling B, Goetzman ES, Sims-Lucas S. J Am Soc Nephrol. 2019 Dec;30(12):2384-2398. doi: 10.1681/ASN.2019020163. PMID: 31575700
The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide. Zhang Y, Bharathi SS, Beck ME, Goetzman ES. Redox Biol. 2019 Sep;26:101253. doi: 10.1016/j.redox.2019.101253. PMID: 31234015
Increased mortality from influenza infection in long-chain acyl-CoA dehydrogenase knockout mice. Shinde A, Luo J, Bharathi SS, Shi H, Beck ME, McHugh KJ, Alcorn JF, Wang J, Goetzman ES. Biochem Biophys Res Commun. 2018 Mar 4;497(2):700-704. doi: 10.1016/j.bbrc.2018.02.135. PMID: 29458021
Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation. Jackson LE, Kulkarni S, Wang H, Lu J, Dolezal JM, Bharathi SS, Ranganathan S, Patel MS, Deshpande R, Alencastro F, Wendell SG, Goetzman ES, Duncan AW, Prochownik EV. Cancer Res. 2017 Nov 1;77(21):5795-5807. doi: 10.1158/0008-5472.CAN-17-1325. PMID: 28883002
Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain. Zhang Y, Bharathi SS, Rardin MJ, Lu J, Maringer KV, Sims-Lucas S, Prochownik EV, Gibson BW, Goetzman ES. J Biol Chem. 2017 Jun 16;292(24):10239-10249. doi: 10.1074/jbc.M117.785022. PMID: 28458255