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Steven William Allen, MD

  • Assistant Professor of Pediatrics
  • Director, Pediatric Bone Marrow Failure Program, UPMC Children's Hospital of Pittsburgh
  • Director, Pediatric Histiocytic Disorder Program, UPMC Children's Hospital of Pittsburgh

Administrative Assistant: Ashley Kosarich

Allen is currently an Assistant Professor of Pediatrics in the Division of Hematology-Oncology at the University of Pittsburgh School of Medicine. He is the director of the Pediatric Bone Marrow Failure Program and the Pediatric Histiocytic Disorder Program. Diagnoses of interest include bone marrow failure (congenital and acquired), myelodysplastic syndrome, histiocytic disorders, leukemia, and lymphoma. 

As a member of the North American Pediatric Aplastic Anemia Consortium (NAPAAC), he is involved in the Bone Marrow Failure Diagnosis and Care Guidelines Working Group and the Myelodysplastic Syndrome Working Group. He is the institutional primary investigator at UPMC Children’s Hospital of Pittsburgh for the NAPAAC-initiated clinical trial "A phase II, open-label, non-controlled, intra-patient dose escalation study to characterize the pharmacokinetics after oral administration of eltrombopag in pediatric patients with refractory, relapsed or treatment naïve severe aplastic anemia or recurrent aplastic anemia.” 

Allen is a member of the Histiocyte Society and North American Consortium for Histiocytosis and involved in the Rare Histiocytic Disorder Working Group. He is also the institutional primary investigator at Children’s for the International Rare Histiocytic Disorders Registry and the clinical trial “LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents with Langerhans Cell Histiocytosis.” 

Within Children’s Hospital as a member of the Fertility Preservation Team, he actively participates in consultation for patients who are at risk of infertility for a variety of reason, in hopes to arrange and offer potential modalities of fertility preservation, including standard of care procedures as well as innovative clinical trial opportunities. As a member of the Leukemia/Lymphoma Working Group, he is actively involved in the development of institutional standard of care guidelines related to our patients with leukemia and lymphoma.

Professional and Scientific Society Memberships

  • Children’s Oncology Group 
  • American Society of Pediatric Hematology Oncology 
  • American Society of Hematology North American Pediatric Aplastic Anemia Consortium 
  • Histiocyte Society 
  • North American Immunohematology Clinical Education and Research Consortium 
  • North American Consortium for Histiocytosis

Education & Training

  • BS, The Pennsylvania State University, 2007
  • MD, The University of Tennessee Health Science Center, 2011
  • Intern/Resident, The University of Tennessee Health Science Center 2014
  • Fellow, Washington University School of Medicine and St. Louis Children's Hospital, 2017

Selected Publications

Burk CM, Coffey KE, Mace EM, Bostwick BL, Chinn IK, Coban-Akdemir ZH, Jhangiani SN, Lupski JR, Ortiz D, Barnum JL, Allen SW, Robertson L, Orange JS, Chong HJ. Immunodeficiency, centromeric instability, and facial anomalies syndrome (ICF) with NK deficiency and EBV-driven malignancy treated with stem cell transplant. Accepted for publication in The Journal of Allergy and Clinical Immunology: In Practice. 

Mastropolo R, Close A, Allen S, McClain KL, Maurer S, Picarsic J. BRAF-V600E mutated Rosai-Dorfman-Destombes disease and Langerhans cell histiocytosis with response to BRAF-inhibitor. Blood Adv. 2019 Jun 25; 3(12): 1848–1853. 

Kothari AK, Allen SW, Willis D, Heigham M, Trinkaus K, Huang FS, Hayashi RJ. Evolution of Optimizing Safety in Chemotherapy Ordering for Pediatric Cancer Patients: Refining of Practices by Integrating Lessons from Reported Errors. Pending submission. 

Allen SW, Hayashi RJ, Jones SJ, Drozda MH, Brown RL, Lackey IT, Price AM, Newland JM, Robinson DL, Carey CJ, Rich ES, Huang FS. Development of Electronic Chemotherapy Roadmaps for Pediatric Oncology Patients. Journal of Pediatric Oncology Nursing. 2018;35(5): 314–319. 

Allen S, Wilson MW, Watkins A, Billups C, Qaddoumi I, Haik BH, Rodriguez-Galindo C. Comparison of Two Methods for Carboplatin Dosing in Children with Retinoblastoma. Pediatr Blood Cancer. 2010 Jul 15;55(1):47-54. 

Freeman SS*, Allen SW*, Ganti R, Wu J, Ma J, Su X, Neale G, Dome JS, Daw NC, Khoury JD. Copy Number Gains in EGFR and Copy Number Losses in PTEN Are Common Events in Osteosarcoma Tumors. Cancer. 2008 Sep 15;113(6):1453-61. * Indicates co-first authorship. 

Full Publication List via NIH PubMed

 

Academic and Research Interests

A phase II, open-label, non-controlled, intra-patient dose escalation study to characterize the pharmacokinetics after oral administration of eltrombopag in pediatric patients with refractory, relapsed or treatment naïve severe aplastic anemia or recurrent aplastic anemia.  

International Rare Histiocytic Disorders Registry 

LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents with Langerhans Cell Histiocytosis 

A Pediatric Trial Using Tranexamic Acid in Thrombocytopenia