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Sucheta Kulkarni, PhD
- Senior Research Scientist
Education & Training
- BS, Zoology, University of Poona (India), 1982
- MS, Zoology, University of Poona, India, 1984
- MPhil, Zoology, University of Poona, India, 1986
- PhD, Life Sciences, University of Bombay, India, 1992
- Fellowship in Experimental Therapeutics, Cleveland Clinic, 1993
- Fellowship in Cancer Biology, Cleveland Clinic, 1995
Selected Publications
Wanitchakool P, Wolf L,Koehl G E,Sirianant L, Schreiber R, Kulkarni S, Duvvuri U, Kunzelmann K.(2014) Role of anoctamins in cancer and apoptosis. Philos Trans R Soc Lond B Biol Sci 369 (1683):201300966. Doi; 10.1098/rstb.2013.0096
Anke Bill, Abraham Gutierrez, Sucheta Kulkarni, Carolyn Kemp, Debora Bonenfant, Hans Voshol, Umamaheswar Duvvuri, L Alex Gaither. (2015) ANO1 interacts with EGFR and correlates with increased sensitivity to EGFR-targeting therapy in head and neck cancer. Oncotarget.6 (11): 9173-9188
Wang H, Lu J, Edmunds L R, Kulkarni S, Dolezal J, Tao J, Ranganathan S, Jackson L, Fromherz M, Beer Stolz D, Uppala R, Bharati S, Monga S P, Goetman E S and Prochownik E V (2016) Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma. J Biol Chem 291(51): 26241-26251
Kulkarni S,Bill A, Godse N R, Khan N I, Kass J I, Steehler K, Kemp C, Davis K, Bertrand C A, Vyas A R, Holt D E, Grandis J R, Gaither L A and Duvvuri U. (2017) TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2. Genes Chromosomes Cancer doi: 10.1002/gcc.22450
Dolezal J M, Wang H, Kulkarni S, Jackson L, Lu J, Ranganathan S, Goetzman E, Bharathi S, Beezhold K, Byersdorfer C and Prochownik E. (2017) Sequential Adaptive Changes in a c-Myc-Driven Model of Hepatocellular Carcinoma. J. Biol Chem: doi:10.1074/jbc.M117.782052
Sucheta Kulkarni, James M. Dolezal, Huabo Wang, Laura Jackson, Jie Lu1, Brian P Frodey, Atinuke Dosunmu-Ogunbi, Youjun Li, Marc Fromherz, Audry Kang, Lucas Santana-Santos, Panayiotis V. Benos and Edward V Prochownik (2017) Ribosomopathy-like Properties of Murine and Human Cancers. PLOS ONE
Laura Jackson, Sucheta Kulkarni, Huabo Wang, Jie Lu, Dolezal James, Sivakama Bharathi, Sarangarajan Ranganathan, Mulchand S Patel, Deshpande R, Alencastro F, Stacey Gelhaus Wendell, Eric S Goetzman, Andrew W Duncan and Edward V Prochownik (2017) Genetic dissociation of glycolysis and the TCA cycle affects neither normal growth nor neoplastic proliferation. Cancer Res; 77(21):5795-5807. Doi: 10. 1158/0008-5472. CAN-17-1325
Huabo Wang, James Dolezal, Sucheta Kulkarni, Jie Lu, Jordan Mandel, Laura E. Jackson, Frances Alencastro, Andrew W. Duncan and Edward V. Prochownik (2018) Myc and ChREBP Transcription Factors Cooperatively Regulate Normal and Neoplastic Hepatocyte Proliferation in mice. J. Biol. Chem; 293(88):14740-14757. doi: 10.1074/jbc. RA118.004099
Huabo Wang,Jie Lu, Sucheta Kulkarni,Joanna Gorka, Jordan Mandel, Goetzman ESandProchownik E (2019) Metabolic and Oncogenic Adaptation to Pyruvate Dehydrogenase Inactivation in fibroblasts. J. Biol. Chem; 294(14):5466-5486. Doi: 10.1074/jbc.RA118.005200.
Wang H, Lu J, Kulkarni S, Zhang W, Gorka JE, Mandel JA, Goetzman ES and Prochownik E (2019) Inhibition of hepatocellular carcinoma by metabolic normalization. PLoS One; 14(6): e0218186. Doi: 10.1371/journal.pone.0218186
Zhang W, Meyfeldt J, Wang H, Kulkarni S, Lu J, Mandel JA, Marburger B, Liu Y, Gorka J, Ranganathan S and Prochownik EV(2019)β-Catenin mutations as determinants of hepatoblastoma phenotypes in mice. J. Biol. Chem; 294(46):17524-17542. Doi: 10.1074/jbc.RA119.009979