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Terence S. Dermody, MD
- Vira I. Heinz Distinguished Professor and Chair of Pediatrics
- Professor of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine
Executive Assistant: Lori Olszewski
Project Coordinator: Lindsey Narron
Terence S. Dermody is the Vira I. Heinz Distinguished Professor and Chair of Pediatrics at the University of Pittsburgh School of Medicine and physician-in-chief and scientific director at UPMC Children’s Hospital of Pittsburgh where he leads a team of over 350 faculty members. He also is professor of microbiology and molecular genetics at the University of Pittsburgh School of Medicine.
Dermody received his B.S. degree from Cornell University and his M.D. degree from Columbia University. He completed an internal medicine residency at Presbyterian Hospital in New York and fellowships in infectious diseases and molecular virology at Brigham and Women’s Hospital and Harvard Medical School. Prior to moving to Pittsburgh in 2016, Dermody was Dorothy Overall Wells Professor of Pediatrics and director of the Medical Scientist Training Program and Division of Pediatric Infectious Diseases at Vanderbilt University School of Medicine.
With over 36 years of experience in basic virology and viral pathogenesis research, at his core, Dermody is a virologist. Most of his research has focused on reovirus, an important experimental model for studies of viral encephalitis in the young. His research contributions have enhanced an understanding of how these viruses enter into host cells and cause organ-specific disease. He has published more than 280 articles, reviews, chapters, and editorials and has been recognized for his research accomplishments by the Vanderbilt Ernest W. Goodpasture Faculty Research Award, an NIH MERIT Award, and the American Society for Microbiology D. C. White Research and Mentoring Award.
Dermody is a member of the American Academy of Microbiology, American Pediatrics Society, American Society for Clinical Investigation, Association of American Physicians, and Society for Pediatric Research and a fellow of the American Association for the Advancement of Science. He is a past president of the American Society for Virology, past chair of the AAMC GREAT Group M.D.-Ph.D. Section Steering Committee, and past chair of the Virology Division of the International Union of Microbiological Societies. Dermody is an editor of the Annual Review of Virology.
Professional and Scientific Society Memberships
- American Society for Microbiology, 1987-Present
- American Association for the Advancement of Science, 1991-Present
- Infectious Disease Society of America, 1991-Present
- American Society for Virology, 1992-Present
- Pediatric Infectious Disease Society, 1992-Present
- Association of Pediatric Program Directors, 1997-Present
- Association of Medical School Pediatric Department Chairs, 2016-Present
Education & Training
- BS with Honors and Distinction, Cornell University, 1978
- MD, Columbia University College of Physicians and Surgeons, 1982
- Internship in Medicine, Presbyterian Hospital, New York, NY, 1982-1983
- Residency in Medicine, Presbyterian Hospital, New York, NY, 1983-1984
- Clinical Fellow in Infectious Diseases, Beth Israel Hospital, Brigham and Women’s Hospital, and Children’s Hospital, 1985-1986
- Research Fellow in Microbiology and Molecular Genetics, Harvard Medical School, Harvard University, 1986-1988
Selected Publications
Barton, E. S., Forrest, J. C., Connolly, J. L., Chappell, J. D., Liu, Y., Schnell, F. J., Nusrat, A., Parkos, C. A., and T. S. Dermody. Junction adhesion molecule is a receptor for reovirus. Cell 104:441-451, 2001. PMID: 11239401
Kobayashi, T., Antar, A. A. R., Boehme, K. W., Danthi, P., Eby, E. A., Guglielmi, K. M., Holm, G. H., Johnson, E. M., Maginnis, M. S., Naik, S., Skelton, W. B., Wetzel, J. D., Wilson, G. J., Chappell, J. D., and T. S. Dermody. A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe. 1:147-157, 2007. PMCID: PMC2034303
Antar, A. A. R., Konopka, J. L., Campbell, J. A., Henry, R. A., Perdigoto, A. L., Carter, B. D., Pozzi, A., Abel, T. W., and T. S. Dermody. Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe. 5:59-71, 2009. PMCID: PMC2642927
Konopka-Anstadt, J. L., Mainou, B. A., Sutherland, D. M., Sekine, Y., Strittmatter, S. M., and T. S. Dermody. The Nogo receptor NgR1 mediates infection by mammalian reovirus. Cell Host Microbe. 15:681-691, 2014. PMCID: PMC4100558
Bouziat, R., Hinterleitner, R., Brown, J. J., […], Dermody, T. S., and B. Jabri. Reovirus infection breaks tolerance to dietary antigens and promotes development of celiac disease. Science. 356:44-50, 2017. PMCID: PMC5506690
Knowlton, J. J., Fernández de Castro, I., Ashbrook, A. W., Gestaut, D. R., Zamora, P. F., Bauer, J. A., Forrest, J. C., Frydman, J., Risco, C., and T. S. Dermody. The TRiC chaperonin controls reovirus replication through outer-capsid folding. Nat. Microbiol. 3:481-493, 2018. PMCID: PMC5874176
Knowlton, J. J., Gestaut, D. R., Ma, B., Taylor, G. M., Seven, A. B., Leitner, A., Wilson, G. J., Shankar, S., Yates, N., Prasad, B. V. V., Aebersold, R., Chiu, W., Frydman, J., and T. S. Dermody. Structural and functional dissection of reovirus capsid folding and assembly by the prefoldin-TRiC/CCT chaperone network. Proc. Natl. Acad. Sci. USA. 118:e2018127118, 2021. PMCID: PMC7980406
Taylor, G. M., Pruijssers, A. J., Brigleb, P. H., Fiske, K., Shang, P., Urbanek, K., Brown, J. J., Rajasundaram, D., and T. S. Dermody. Neural-cell-intrinsic NF-κB signaling enhances reovirus virulence. J. Virol. 97:e01442-22, 2023. PMCID: PMC9888206
Shang, P., Simpson, J. D., Taylor, G. M., Sutherland, D. M., Welsh, O. L., Aravamudhan, P., Dos Santos Natividade, R., Schwab, K., Michel, J. J., Poholek, A., Wu, Y., Rajasundaram, D., Koehler, M., Alsteens, D., and T. S. Dermody. Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus. Nat. Commun. 14:2615, 2023. PMCID: PMC10163058
Sutherland, D. M., Streßl, M., Koehler, M., Welsh, O. L., Yu, X., Hu, L., Dos Santos Natividade, R., Knowlton, J. J., Taylor, G. M., Moreno, R. A., Wörz, P., Lonergan, Z. R., Aravamudhan, P., Guzman-Cardozo, C., Kour, S., Pandey, U. B., Alsteens, D., Wang, Z., Prasad, B. V. V., Stehle, T., and T. S. Dermody. NgR1 binding to reovirus reveals an unusual bivalent interaction and a new viral attachment protein. Proc. Natl. Acad. Sci. USA. 120:e2219404120, 2023. PMCID: PMC10268256
Academic and Research Interests
- Virology
- Viral pathogenesis
- Viral receptors
- Vaccine development
- Reovirus
- Viral encephalitis
- Celiac disease
- Genetic screens
- Protein structure-function relationships
- Mouse models of disease
Research Grants
2019-2024 “Cell Biology of Reovirus Infection” (NIH-NIAID R01 AI032539-28 to -32). T. S. Dermody, P.I.
2021-2026 “Effects of Reoviridae Assembly and Transmission Processes on Viral Genetic Diversity” (NIH-NIAID R01 AI155646-01 to -05). K. M. Ogden, P.I., T. S. Dermody, Co-Investigator
2022-2027 “Reovirus Neuropathogenesis” (NIH-NIAID R01 AI174526-01 to -05). T. S. Dermody, P.I.
2023-2028 “Role of Gut Protists in Celiac Disease” (NIH-NIAID R01 AI168478-01 to -05). R. Hinterleitner, P.I., T. S. Dermody, Co-Investigator
2023-2028 “Enteric Virus-Microbiota Interactions” (NIH-NIAID R01 AI074668-15 to -19). J. Pfeiffer, P.I., T. S. Dermody, Co-Investigator
2020-2025 “Research Training Program for Pediatric Subspecialty Fellows” (NIH-NICHD T32 HD071834-06 to -10). T. S. Dermody, P.I.
2023-2027 “Molecular Basis of Pediatric Disease” (NIH-NICHD K12 HD052892-16 to -20).