Terence S. Dermody, MD

  • Vira I. Heinz Distinguished Professor and Chair of Pediatrics
  • Professor of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine
  • Physician-in-Chief and Scientific Director, UPMC Children’s Hospital of Pittsburgh

Executive Assistant: Miranda F. Feldmann, MS

Dr. Terence S. Dermody is the Vira I. Heinz Distinguished Professor and Chair of Pediatrics at the University of Pittsburgh School of Medicine and Physician-in-Chief and Scientific Director at UPMC Children’s Hospital of Pittsburgh.

Dr. Dermody received his B.S. degree from Cornell University and his M.D. degree from Columbia University. He completed an internal medicine residency at Presbyterian Hospital in New York and fellowships in infectious diseases and molecular virology at Brigham and Women’s Hospital and Harvard Medical School. Prior to moving to Pittsburgh in 2016, Dr. Dermody was Dorothy Overall Wells Professor of Pediatrics and Director of the Medical Scientist Training Program and Division of Pediatric Infectious Diseases at Vanderbilt University School of Medicine.

Dr. Dermody is a virologist with interests in viral pathogenesis and vaccine development. Most of his research has focused on reovirus, an important experimental model for studies of viral encephalitis in the young, and chikungunya virus, an emerging mosquito-borne virus that causes epidemics of fever and arthritis. His research contributions have enhanced an understanding of how these viruses enter into host cells and cause organ-specific disease. He has published more than 250 articles, reviews, chapters, and editorials and has been recognized for his research accomplishments by the Vanderbilt Ernest W. Goodpasture Faculty Research Award, an NIH MERIT Award, and the American Society for Microbiology D. C. White Research and Mentoring Award.

Professional and Scientific Society Memberships

  • American Society for Microbiology, 1987-Present
  • American Association for the Advancement of Science, 1991-Present
  • Infectious Disease Society of America, 1991-Present
  • American Society for Virology, 1992-Present
  • Pediatric Infectious Disease Society, 1992-Present
  • Association of Pediatric Program Directors, 1997-Present
  • Association of Medical School Pediatric Department Chairs, 2016-Present

Education & Training

  • BS with Honors and Distinction, Cornell University, 1978
  • MD, Columbia University College of Physicians and Surgeons, 1982
  • Internship in Medicine, Presbyterian Hospital, New York, NY, 1982-1983
  • Residency in Medicine, Presbyterian Hospital, New York, NY, 1983-1984
  • Clinical Fellow in Infectious Diseases, Beth Israel Hospital, Brigham and Women’s Hospital, and Children’s Hospital, 1985-1986
  • Research Fellow in Microbiology and Molecular Genetics, Harvard Medical School, Harvard University, 1986-1988

Selected Publications

Barton, E. S., Forrest, J. C., Connolly, J. L., Chappell, J. D., Liu, Y., Schnell, F. J., Nusrat, A., Parkos, C. A., and T. S. Dermody. Junction adhesion molecule is a receptor for reovirus. Cell 104:441-451, 2001. PMID: 11239401

Ebert, D. H., Deussing, J., Peters, C., and T. S. Dermody. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblasts. J. Biol. Chem. 277:24609-24617, 2002. PMID: 11986312

Kobayashi, T., Antar, A. A. R., Boehme, K. W., Danthi, P., Eby, E. A., Guglielmi, K. M., Holm, G. H., Johnson, E. M., Maginnis, M. S., Naik, S., Skelton, W. B., Wetzel, J. D., Wilson, G. J., Chappell, J. D., and T. S. Dermody. A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe. 1:147-157, 2007. PMCID: PMC2034303

Kirchner, E., Guglielmi, K. M., Strauss, H., Dermody, T. S., and T. Stehle. Structure of reovirus σ1 in complex with its receptor junctional adhesion molecule-A. PLoS Pathog. 4:e1000235, 2008. PMCID: PMC2588538

Antar, A. A. R., Konopka, J. L., Campbell, J. A., Henry, R. A., Perdigoto, A. L., Carter, B. D., Pozzi, A., Abel, T. W., and T. S. Dermody. Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe. 5:59-71, 2009. PMCID: PMC2642927

Boehme, K. W., Guglielmi, K. M., and T. S. Dermody. Reovirus nonstructural protein σ1s is required for establishment of viremia and systemic dissemination. Proc. Natl. Acad. Sci. USA. 106:19986-19991, 2009. PMCID: PMC2774258

Bouziat, R., Hinterleitner, R., Brown, J. J., Stencel-Baerenwald, J. E., Ikizler, M., Mayassi, T., Meisel, M., Kim, S. M., Discepolo, V., Pruijssers, A. J., Ernest, J. D., Iskarpatyoti, J. A., Costes, L. M. M., Lawrence, I., Palanski, B. A., Varma, M., Zurenski, M. A., Khomandiak, S., McAllister, N., Aravamudhan, P., Boehme, K. W., Hu, F., Samsom, J. N., Reinecker, H.-C., Kupfer, S. S., Guandalini, S., Semrad, C. E., Abadie, V., Khosla, C., Barreiro, L. B., Xavier, R. J., Ng, A., Dermody, T. S., and B. Jabri. Reovirus infection breaks tolerance to dietary antigens and promotes development of celiac disease. Science. 356:44-50, 2017. PMCID: PMC5506690 

Knowlton, J. J., Fernández de Castro, I., Ashbrook, A. W., Gestaut, D. R., Zamora, P. F., Bauer, J. A., Forrest, J. C., Frydman, J., Risco, C., and T. S. Dermody. The TRiC chaperonin controls reovirus replication through outer-capsid folding. Nat. Microbiol. 3:481-493, 2018. PMCID: PMC5874176

Aravamudhan, P., Raghunathan, K., Konopka-Anstadt, J., Pathak, A., Sutherland, D. M., Carter, B. D., and T. S. Dermody. Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons. PLoS Pathog. 16:e1008380, 2020. PMCID: PMC7065821

Fernández de Castro, I., Tenorio, R., Ortega-González, P., Knowlton, J. J., Zamora, P. F., Lee, C. H., Mainou, B. A., Fernández, J. J., Dermody, T. S., and C. Risco. A modified lysosomal organelle mediates non-lytic egress of reovirus. J. Cell Biol. 219:e201910131, 2020. PMCID: In progress

Full Publication List via NIH PubMed »

Research Interest Summary

Virology and Vaccine Development

Research Interests

  • Pathogenesis of viral infections
  • Viral attachment and cell entry
  • Replication of dsRNA viruses
  • Virus-induced apoptosis
  • Development of antiviral vaccines 

Research Grants

“Reovirus Attachment Mechanisms” (NIH-NIAID R01 AI118887-01 to - 05). T. S. Dermody, P.I. (16% effort). Direct costs, $1,743,107. (2015-2020)

“Chikungunya Virus Replication and Pathogenesis” (NIH-NIAID R01 AI123348-01 to -05). T. S. Dermody (contact), M. S. Diamond, and T. E. Morrison, Co-Principal Investigators (15% effort). Direct costs (Dermody component), $968,070 (2016-2021)

“The Molecular Basis of Reovirus Pathogenesis” (NIH-NIAID R01 AI038296-22 to -25). T. S. Dermody, P.I. (16% effort). Direct costs, $1,190,135. (2016-2020)

“Cell Biology of Reovirus Infection” (NIH-NIAID R01 AI032539-28 to - 32). T. S. Dermody, P.I. (16% effort). Direct costs, $2,203,670. (2019-2024)

“Viral Infections and Celiac Disease Pathogenesis” (NIH-NIDDK R01 DK098435-05 to -09). T. S. Dermody and B. Jabri (contact), Co-Principal Investigators (16% effort). Direct costs (Dermody component), $721,233. (2019-2023)

“Molecular Basis of Pediatric Disease” (NIH-NICHD K12 HD052892-11 to -15). T. S. Dermody, P.I. (10% effort). Total costs, $2,221,104. (2017-2022)

“Research Training Program for Pediatric Subspecialty Fellows” (NIHNICHD T32 HD071834-06 to -10). T. S. Dermody, P.I. (10% effort). Total costs, $2,292,768. (2020-2025)