Thomas G. Diacovo, MD, PhD, FACMG

  • Division Director, Newborn Medicine and Professor of Pediatrics and Pharmacology and Chemical Biology
  • Chief, UPMC Division of Newborn Medicine
  • Director of Neonatal Cardiovascular Research, UPMC Children's Hospital of Pittsburgh Heart Institute

Administrative Assistant: Cindy Vogt

Professional and Scientific Society Membership

  • American Society of Pediatric Research (elected), 1998-Present
  • American Society of Hematology, 1996-Present
  • American Heart Association, 2000-Present
  • International Society of Thrombosis and Hemostasis (ISTH), 2002-Present
  • North American Society on Thrombosis and Hemostasis, 2014-Present
  • International Neonatal Consortium (INC), Council Member, 2014-Present

Education & Training

  • BSc, Biochemistry with Honors, McGill University, 1984
  • MD, McGill University, 1988
  • Internship in Pediatrics, Baylor College of Medicine, 1988-1989
  • Residency in Pediatrics, Baylor College of Medicine, 1989-1991
  • Joint Program in Neonatology, Brigham and Women's Hospital, 1991-1994

Selected Publications

Lauren E Kelly, Kimberly Caswell, Mary Short, Prabhu S Parimi, Martin Offringa, Thomas Diacovo. Response biomarkers in neonatal intervention studies. Pediatr Res. 2017, on-line. PMID:29278643

Kaza E, Egalka M, Zhou H, Chen J, Evans D, Pratts J, Li R, Diamond SL, Vincent J, Bacha E, Diacovo TG. P2Y12Receptor Function and Response to Cangrelor in Neonates with Cyanotic Congenital Heart Disease. JACC, BTS. 2017. 2(4):465-476. PMID:29057376

Rotemberg V, Lauren C, Garzon M, Iglesias A, Brachio S, Aggarwal V, Stong N, Goldstein D, Diacovo T. A Novel Mutation in Junctional Plakoglobin Causing Lethal Congenital Epidermolysis Bullosa. J Pediatr. 2017.191:266-269.PMID:29173316

Efimenko E, Davé UP, Lebedeva IV, Shen Y, Sanchez-Quintero MJ, Diolaiti D, Kung A, Lannutti B, Chen J, Realubit R, Niatsetskiya Z, Ten V, Karan C, Chen X, Califano A, Diacovo TG. PI3K and NOTCH1 cross-regulate pathways that define the T-cell acute lymphoblastic leukemia disease signature. Mol Cancer Ther. 2017. 16(10):2069-2082. PMID:28716817

Torok RD, Li JS, Kannankeril PJ, Atz AM, Bishai R, Bolotin E, Breitenstein S, Chen C, Diacovo T, Feltes T, Furlong P, Hanna M, Graham EM, Hsu D, Ivy DD, Murphy D, Kammerman LA, Kearns G, Lawrence J, Lebeaut B, Li D, Male C, McCrindle B, Mugnier P, Newburger JW, Pearson GD, Peiris V, Percival L, Pina M, Portman R, Shaddy R, Stockbridge NL, Temple R, Hill KD. Recommendations to Enhance Pediatric Cardiovascular Drug Development: Report of a Multi-Stakeholder Think Tank. J Am Heart Assoc. 2018. 10;7(4). PMID:29440007

Max K, Bertram K, Akat MC, Bogardus KA, Li J, Morozov P, Ben-Dov IZ, Li X, Weiss ZR, Azizian A, Sopeyin A, Diacovo TG, Adamidi C, Williams Z, Thomas Tuschl. Human plasma and serum extracellular small RNA reference profiles and their clinical utility. PNAS 2018. 5;115(23):E5334-E5343. PMID: 29777089

Lee KM, Diacovo TG, Calderon J, Byrne MW, Ing C. Outcomes Research in Vulnerable Pediatric Populations. J Neurosurg Anesthesiol. 2019. 31(1):140-143. PMID:30767939

Das S, Extracellular RNA Communication Consortium, Ansel KM, Bitzer M, Breakefield XO, Charest A, Galas DJ, Gerstein MB, Gupta M, Milosavljevic A, McManus MT, Patel T, Raffai RL, Rozowsky J, Roth ME, Saugstad JA, Van Keuren-Jensen K, Weaver AM, Laurent LC. The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research. Cell. 2019 Apr 4;177(2):231-242. PMID: 30951667

Akat KM, Lee YA, Hurley A, Morozov P, Max KE, Brown M, Bogardus K, Sopeyin A, Hildner K, Diacovo TG, Neurath MF, Borggrefe M, Tuschl T. Detection of circulating extracellular mRNAs by modified small-RNA-sequencing analysis. JCI Insight. 2019 Apr 11;5. PMID:30973829

Vargas D, Zhou H, Yu X, Diamond S, Yeh J, Allada V, Krishnamurthy G, Price M, Allen B, Alexander J, Schmidhofer J, Kreutzer J, Vincent J, Morell V, Bacha E, Diacovo T.  Cangrelor PK / PD and Safety Study in Neonates Following Palliative Surgery for Congenital Heart Disease. Submitted May 2020. 

Full Publication List via NIH PubMed »

Research Interests

  • Novel blood products for neonates
  • New therapies to treat necrotizing enterocolitis
  • Regulation of T cell function to treat GVHD
  • Targeted therapies for leukemia and thrombosis

Research Grants

Applied Therapeutics, Evaluation of a novel dual PI3K gamma / delta inhibitor (PI), 2020-2021, $69,097 direct costs.

Magee-Womens Research Institute and Foundation, Developing age-appropriate blood products for critically-ill newborns (PI), 2020-2022, $200,000 annual direct costs.

Cellphire, Inc., Preclinical evaluation of the hemostatic and thrombogenic properties thrombosomes (PI), 2020, $112,786 direct costs.

Richard King Mellon Foundation, Infant Mortality Risk Reduction Initiative (PI, NICU clinical leadership team), 2019-2022, $273,275 annual direct costs.

Lemieux Foundation, Novel anticlotting agents and detection system for newborns with CHD (PI), 2018-2020, $75,000 annual direct costs.

NIH 1R01HD081281-01, Neonatal and Pediatric Platelet Function and Pharmacology (Co-PI, Diamond/Diacovo), 2015-2020.

NIH 1U01TR002271-01, Precision Medicine in the Diagnosis of Genetic Disorders in Neonates (Site Co-PI - Vockley/Diacovo, PI: Davis), 2019-2022.