Xiaoyan Gong, MD

  • Research Scientist

Dr. Xiaoyan Gong currently works in Dr. Raymond Frizzell’s cystic fibrosis research team at department of pediatrics in Rangos Research Center. She is an extensive experienced biomedical researcher with a broad background in medical and biology research. Her research studies include identifying and understanding the role of small molecules, chaperons and post-translational modification pathways, like SUMOylation pathway and Ubiquitination pathway, in the regulation of biogenesis and degradation of cystic fibrosis transmembrane conductance regulator in cystic fibrosis (CF) diseases. As the first author or co-author, her research work has been published in 10 peer-reviewed articles and over 15 published research abstracts. She was also invited several times to present her research studies on international conferences.

Education & Training

  • MD, West China Medical School, 1999

Selected Publications

Liu S, Gallo DJ, Green AM, Williams DL, Gong X, Shapiro RA, Gambotto AA, Humphris EL, Vodovotz Y, Billiar TR. Role of Toll-like Receptors in Changes in Gene Expression and NF-kappa B Activation in Mouse Hepatocytes Stimulated with Lipopolysaccharide. Infect Immun. 2002 Jul;70(7):3433-42. PubMed PMID: 12065483. 

Sun F, Zhang R, Gong X, Geng X, Drain PF, Frizzell RA. Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants. J Biol Chem. 2006 Dec 1;281(48):36856-63. PubMed PMID: 16954204. 

Sun F, Mi Z, Condliffe SB, Bertrand CA, Gong X, Lu X, Zhang R, Latoche JD, Pilewski JM, Robbins PD, Frizzell RA.Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. FASEB J. 2008 Sep;22(9):3255-63. PubMed PMID: 18556464. 

Gong X, McGee EA. Smad3 is required for normal follicular follicle-stimulating hormone responsiveness in the mouse. Biol Reprod. 2009 Oct;81(4):730-8. PubMed PMID: 19535790. 

Ahner A, Gong X, Schmidt BZ, Peters KW, Rabeh WM, Thibodeau PH, Lukacs GL, Frizzell RA. Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier-dependent pathway. Mol Biol Cell. 2013 Jan;24(2):74-84. PubMed PMID:     23155000. 

Ahner A, Gong X, Frizzell RA. Cystic fibrosis transmembrane conductance regulator degradation: cross-talk between the ubiquitylation and SUMOylation pathways. FEBS J. 2013 Sep;280(18):4430-8. PubMed PMID: 23809253. 

Gong X, Ahner A, Roldan A, Lukacs GL, Thibodeau PH, Frizzell RA. Non-native conformers of CFTR NBD1 are recognized by Hsp27 and conjugated to SUMO-2 for degradation. J Biol Chem. 2016 Jan 22;291(4):2004-17. PubMed PMID: 26627832. 

Ahner A, Gong X, Frizzell RA. Divergent signaling via SUMO modification: Potential for CFTR modulation. Am J Physiol Cell Physiol. 2016 Feb 1;310(3):C175-80. PubMed PMID: 26582473. 

Ernst WL, Shome K, Wu CC, Gong X, Frizzell RA, Aridor M. VAP (VAMP-Associated Proteins) as Receptors that couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis. J Biol Chem. 2016 Mar 4;291(10):5206-20. PubMed PMID: 26740627. 

Gong X, Liao Y, Ahner A, Larsen MB, Wang X, Bertrand CA, Frizzell RA. The effect of some local anesthetic compounds on sarcotubular calcium transport.  SUMO E3 ligase, PIAS4, stabilizes F508del CFTR via SUMOylation. Mol Biol Cell. 2019 Jan 1;30(1):4-16. PubMed PMID: 30403549.