Xiaoyi (Tina) Zhang, MD, PhD

  • Fellow

Originally born in China, Tina Zhang moved to the United States at age 4, spending most of her childhood in South Carolina. She received her undergraduate degree at the University of South Carolina in Columbia, SC, before entering the Medical Scientist Training Program at the Medical University of South Carolina in Charleston, SC, where she earned her medical and doctorate degrees in 2016. Her doctoral research training in regulation of the immune system within the oral cavity in head and neck cancer then developed into broader questions of how the immune system regulates itself between effectively battling infections and controlling the development of autoimmunity and chronic inflammation, particularly within the gastrointestinal tract. After completing her pediatric residency at the Medical University of South Carolina, she began her pediatric gastroenterology at the University of Pittsburgh Medical Center Children’s Hospital of Pittsburgh in 2018, where she will continue for four years in an Accelerated Research Pathway through the American Board of Pediatrics to pursue a career in academic research. 

Education & Training

  • BS, Biological Sciences, University of South Carolina, 2008
  • MD, PhD, Molecular, Cellular Biology and Pathobiology, Cancer Biology, Medical University of South Carolina, 2016
  • Pediatric Residency, Medical University of South Carolina, 2016-2018
  • Pediatric Gastroenterology Fellowship, UPMC Children's Hospital of Pittsburgh, 2018-2022

Selected Publications

X. Zhang, J.A. Stewart, Jr., I.D. Kane, E.P. Massey, D.O. Cashatt, and W.E. Carver. Effects of elevated glucose levels on interactions of cardiac fibroblasts with the extracellular matrix. In Vitro Cellular & Development Biology – Animal. 2007. 43(8-9):297-305. PMID: 17849168.

T.H. Beckham, P. Lu, J.C. Cheng, D. Zhao, L.S. Turner, X. Zhang, K.E. Armeson, A. Liu, S.T. Marrison, Y.A. Hannun, and X. Liu. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer. 2012 Nov; 131(9):2034-43. PMID: 22322590.

X. Zhang, C. Rossa, Jr., M. Liu, F. Li, N.J. D’Silva, and K.L. Kirkwood. Oral squamous carcinoma cells secrete RANKL directly supporting osteolytic bone loss. Oral Oncology. 2013 Feb; 49(2):119-28. PMID: 22989723.

X. Zhang, M. Hyer, H. Yu, N.J. D’Silva, and K.L. Kirkwood. DUSP1 phosphatase regulates the proinflammatory milieu in head and neck squamous cell carcinoma. Cancer Research. 2014 Dec; 74(24):7191-7. PMID: 25312268.

X. Zhang, B. Donnelly, J. Thomas, L. Sams, K. O’Brien, S.N. Taylor, and C.S. Jump. Growth in the High-Risk Newborn Infant Post-Discharge: Results from a Neonatal Intensive Care Unit Nutrition Follow-up Clinic. Nutrition in Clinical Practice. 2019. In press.

C. Rauscher, M. Reyes-Mugica, E. Cassidy, R. Shupak, X. Zhang, and H. Chong. Unexpected Oral Lesions in a Patient with a Novel Cytotoxic T-lymphocyte Antigen-4 (CTLA-4) Variant - A Case Report. J Clin Immunol. 2020. In press.