Yudong Wang, PhD
- Research Assistant Professor of Pediatrics
Yudong Wang, PhD is an accomplished research assistant professor with extensive knowledge and experience in mitochondrial respiratory chain and fatty acid oxidation (FAO). His primary research focus is on the structural and functional connections between fatty acid oxidation enzymes and the electron transport chain complex, a hypothesis he originally established and first published in 2010 in the Journal of Biochemistry, with a follow-up publication in the same scientific journal in 2019. These results, thus far, have shown the existence of their structural and functional linkages, which contribute significantly to the mitochondria’s ability to produce ATP, the energy currency of cells. Wang's work in this area has also led to significant experience with the structural and functional assays necessary to describe the multifunctional FAO complex and its interactions with respiratory chain supercomplexes.
In addition to his list of publications, Wang has also contributed to the teaching and mentoring of those that have come and passed through the lab, including medical fellows and international scholars, graduate students, and undergraduates, as well as numerous technicians and research scientists. He has also partaken in many projects from other labs who are collaborators of Jerry Vockley, MD, PhD, FACMG. Besides contributing to basic research in mitochondrial energy metabolism, Wang is also focusing on the clinical ramifications of his research, in the hopes that it can contribute to the development of energy metabolism disorders’ diagnoses and treatments.
Professional and Scientific Society Memberships
- Mitochondria Research Society, 2001-Present
Education & Training
- BS, Agronomy, China Agricultural University, 1969
- MS, Plant Biochemistry and Biophysics, China Agricultural University, 1981
- PhD, Plant Biochemistry and Biophysics, China Agricultural University, 1987
- Postdoctoral Research, Biochemistry, West Virginia University School of Medicine, 1989-1994
*Goetzman ES, *Wang Y, He M, Mohsen AW, Ninness BK, Vockley J. Expression and characterization of mutations in human very long-chain acyl-CoA dehydrogenase using a prokaryotic system. Mol Genet Metab. 2007 Jun;91(2):138-47. Epub 2007 Mar 19. PMID: 17374501. *Equal Contributors
McAndrew RP, Wang Y, Mohsen AW, He M, Vockley J, Kim JJ. Structural basis for substrate fatty-acyl chain specificity: Crystal structure of human very-long-chain acyl-coa dehydrogenase. J Biol Chem. 2008 Apr 4;283(14):9435-43. PMID: 18227065.
Wang Y, Mohsen AW, Mihalik SJ, Goetzman ES, Vockley J. Evidence for physical association of mitochondrial fatty acid oxidation and oxidative phosphorylation complexes. J Biol Chem. 2010 Sep 24;285(39):29834-41. PMID: 20663895.
Graves JA, Wang Y, Sims-Lucas S, Cherok E, Rothermund K, Branca MF, Elster J, Beer-Stolz D, Van Houten B, Vockley J, Prochownik EV. Mitochondrial Structure, Function and Dynamics Are Temporally Controlled by c-Myc. PLoS One. 2012;7(5):e37699. PMID: 22629444.
Sarin M, Wang Y, Zhang F, Rothermund K, Zhang Y, Lu J, Sims-Lucas S, Beer-Stolz D, Van Houten BE, Vockley J, Goetzman ES, Graves JA, Prochownik EV. Alterations in c-Myc phenotypes resulting from dynamin-related protein 1 (Drp1)-mediated mitochondrial fission. Cell Death Dis. 2013 Jun 13;4:e670. PMID: 23764851.
Chaly Y, Fu Y, Marinov A, Hostager B, Yan W, Campfield B, Kellum JA, Bushnell D, Wang Y, Vockley J, Hirsch R. (2014). Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1beta secretion from monocytes and macrophages. Eur J Immunol. 2014 May;44(5):1467-79. PMID: 24470197.
Schiff M, Haberberger B, Xia C, Mohsen AW, Goetzman ES, Wang Y, Uppala R, Zhang Y, Karunanidhi A, Prabhu D, Alharbi H, Prochownik EV, Haack T, Haberle J, Munnich A, Rotig A, Taylor RW, Nicholls RD, Kim JJ, Prokisch H, Vockley J. (2015). Complex I assembly function and fatty acid oxidation enzyme activity of ACAD9 both contribute to disease severity in ACAD9 deficiency. Hum Mol Genet. 2015 Jun 1;24(11):3238-47. PMID: 25721401.
Casinelli G, LaRosa J, Sharma M, Cherok E, Banerjee S, Branca M, Edmunds L, Wang Y, Sims-Lucas S, Churley L, Kelly S, Sun M, Stolz D, Graves JA. N-Myc overexpression increases cisplatin resistance in neuroblastoma via deregulation of mitochondrial dynamics. Cell Death Discov. 2016 Dec 12;2:16082. PMID: 28028439
Bloom K, Mohsen AW, Karunanidhi A, El Demellawy D, Reyes-Múgica M, Wang Y, Ghaloul-Gonzalez L, Otsubo C, Tobita K, Muzumdar R, Gong Z, Tas E, Basu S, Chen J, Bennett M, Hoppel C, Vockley J. Investigating the link of ACAD10 deficiency to type 2 diabetes mellitus. J Inherit Metab Dis. 2018 Jan;41(1):49-57. PMID: 28120165.
Seminotti B, Leipnitz G, Karunanidhi A, Kochersperger C, Roginskaya VY, Basu S, Wang Y, Wipf P, Van Houten B, Mohsen AW, Vockley J. Mitochondrial energetics is impaired in very long-chain acyl-CoA dehydrogenase deficiency and can be rescued by treatment with mitochondria-targeted electron scavengers. Hum Mol Genet. 2019 Mar 15;28(6):928-941. PMID: 30445591
Wang Y, Palmfeldt J, Gregersen N, Makhov AM, Conway JF, Wang M, McCalley SP, Basu S, Alharbi H, St Croix C, Calderon MJ, Watkins S, Vockley J. Mitochondrial fatty acid oxidation and the electron transport chain comprise a multifunctional mitochondrial protein complex. J Biol Chem. 2019 Aug 16;294(33):12380-12391. PMID: 31235473
Academic and Research Interests
- The physical interaction between fatty acid oxidation and respiratory chain.
- The effects of the electron transfer chain in fatty acid oxidation patients.
- The effects of the fatty acid oxidation in the electron transfer chain mutation patients.
- The oxidative damage in the fatty acid oxidation mutation cells.
- Functional change of mitochondria in carcinogenic cells