Zhenwei Gong, PhD
- Research Assistant Professor
Dr. Gong's research interest is focused on investigating the role of inflammasomes in energy metabolism and glucose homeostasis.
Education & Training
- BS, Biotechnology, Northeast Normal University, 2002
- MS, Cytology, Northeast Normal University, 2005
- PhD, Biochemistry and Molecular Biology, Chinese Academy of Sciences, 2009
Gong Z #, Zhang X, Su K, Jiang R, Sun Z, Chen W, Forno E, Goetzman ES, Wang J, Dong HH,Dutta P, Muzumdar R #. Deficiency in AIM2 induces inflammation and adipogenesis in whiteadipose tissue leading to obesity and insulin resistance. Diabetologia. 2019. (# co-corresponding author)
Gong Z, TassetI, Diaz A, AnguianoJ, TasE, CuiL, KuliawatR, LiuH, KühnB, CuervoAM and MuzumdarM.Humanin is an endogenous activator of chaperone-mediated autophagy. JCell Biology2018
Liu Z, Cordoba-Chacon J, Kineman RD, Cronstein BN, Muzumdar R, Gong Z, Werner H and YakarS. Growth hormone control of hepatic lipid metabolism. Diabetes. 2016Dec.
Gong Z, Su K, Cui L, Tas E, Zhang T, Dong HH, Yakar S and Muzumdar RH. Central effects of humanin in hepatic triglyceride secretion. AJP Endocrinology and Metabolism. 2015Aug.
Gong Z*, Kennedy O*, Sun H*, Wu Y*, Williams GA, Klein L, Cardoso L, Basta-Pljakic J, Adamo ML, Matheny RW, Hubbard GB, Ikeno Y, Schaffler MB, Muzumdar RH, Yakar S. Reductions in serum IGF-1 during aging impair health span. Aging Cell, 2013.Jun
Mansuy-Aubert V*, Zhou QL*, Xie X*, Gong Z,Huang JY, Khan AR, Aubert G, Candelaria K, Thomas S, Shin DJ, Booth S, Baig SM, Bilal A, Hwang D, Zhang H, Lovell-Badge R, Smith SR, Awan FR, Jiang ZY. Imbalance between Neutrophil Elastaseand its Inhibitor α1-Antitrypsin in Obesity Alters Insulin Sensitivity, Inflammation, and Energy Expenditure. Cell Metab.2013Apr.(*authors contributed equally)
Xie X*, Gong Z*, Mansuy-Aubert V*, Zhou QL, Tatulian SA, Sehrt D, Gnad F, Brill LM, Motamedchaboki K, Chen Y, Czech MP, Mann M, Krüger M, Jiang ZY. C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab. 2011Sep.(*authors contributed equally)
Cui G, Qin X, Zhang Y, Gong Z, Ge Band Zang YQ. Berberine differentially modulates the activities of Erk, p38 MAPK and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice.J Biol Chem.2009.Oct.
Cui G, Zhang Y, Gong Z, Zang YQ. Induction of the CD4+CD25+Foxp3+ regulatory T cell response by Glatiramer Acetate in murine models of type 1 diabetes. Cell Res.2009.May
Gong Z, Huang C, Sheng X, Zhang Y, Li Q, Wang M, Peng L, Zang YQ. The role of Tanshinone IIA in the Treatment of Obesity through PPARγ Antagonism. Endocrinology2009.Jan.
National institute of Health/ NHLBI, R-56, Co-I, Cardioprotective Role of Humanin, 2018-2020