Recent Publications

2018

Revu S, Wu j, Henkel M, Rittenhouse N, Menk A, Delgoffe GM, Poholek AC, McGeachy MJ. IL-23 and IL-1β drive human Th17 cell differentiation and metabolic reprogramming in the absence of CD28 costimulation. Cell Reports. Mar 6;22(10):2642-2653. 2018. 

Samuelsen S, Jørgensen CD, Mellins ED, Torok KS, Astakhova K (2018) Detection of autoimmune antibodies in localized scleroderma by synthetic oligonucleotide antigens. PLoS One. 2018 Apr 11;13(4):e0195381. doi: 10.1371/journal.pone.0195381. eCollection 2018. PMID:29641558 

Camison L, Mai RS, Goldstein GA, Costello BJ, Torok KS, Losee JE. “Chronic Recurrent Multifocal Osteomyelitis of the Mandible: A Diagnostic Challenge”. Plastic and Reconstructive Surgery. Publish Ahead of Print():, MAR 2018.  DOI: 10.1097/PRS.0000000000004494; PMID: 29652766 

Constantin T, Foeldvari I, Pain CE, Palinkas A, Höger P, Moll, M, Nemkova D, Weibel L, Laczkovski M, Clements P and Torok KS. Development of Minimum Standards of Care for Juvenile Localized Scleroderma. European Journal of Pediatrics. Accepted: 4 April 2018, part of Springer Nature 2018. https://doi.org/10.1007/s00431-018-3144-8. PMID: 29728839 

Stevens BS, Torok KS, Li Sc, Hershey N, Curran M, Higgins GC, Moore KF, Rabinovich CE, Dodson S, Stevens A,  and The CARRA Registry Investigators. Clinical Characteristics and factors associated with disability and impaired quality of life in children with juvenile systemic sclerosis. Arthritis Care & Research 2018 Feb 18. doi: 10.1002/acr.23547. [Epub ahead of print] PMID: 29457372 

Ardalan K, Switzer GE, Zigler CK, Hershey NM, Torok KS.  Psychometric properties of the Children's Dermatology Life Quality Index in pediatric localized scleroderma. Journal of Scleroderma and Related Disorders. Accepted Jan 2018. DOI: 10.1177/2398198318760768 

Li SC, Li X, Pope E, Stewart K, Higgins GC, Rabinovich CE, O'Neil KM, Haines KA, Laxer RM, Punaro M, Jacobe H, Andrews T, Wittkowski K, Nyirenda T, Foeldvari I, Torok KSNew Features for Measuring Disease Activity in Pediatric Localized Scleroderma. J Rheumatol. 2018 Sep 15. pii: jrheum.171381. doi: 10.3899/jrheum.171381. [Epub ahead of print] PubMed PMID: 30219769. 

Mirizio, E., Marathi, A., Hershey, N., Ross, C., Schollaert, K., Salgadgo, C. M., Reyes-Mugica, M. & Torok, K.S. (2018).  Identifying the signature immune phenotype present in pediatric Localized Scleroderma.  Journal of Investigative Dermatology.  Accepted September 24, 2018.   

Ferguson ID, Griffin P, Yano H, Gaffen SL, Piganelli JD, Dvergsten JA, Michel JJ, Rosenkranz ME, Kietz DA, Vallejo AN. 2018. CD31/IL17-driven inflammatory axis shapes synovitis in juvenile idiopathic arthritis. Frontiers Immunol 9:1802 doi: 10.3389/fimmu.2018.01802. 

Smagula SF, Karim HT, Rangarajan A, Santos FP, Wood SC, Santini T, Jakicic JM, Reynolds CF, Cameron JL, Vallejo AN, Butters MA, Rosano C, Ibrahim TS, Erickson KI, Aizenstein HJ. 2018. Association of hippocampal substructure resting-state functional connectivity with memory performance in older adults. Am J Geriatr Psychiat 26(6):690-699.  doi: 10.1016/j.jagp.2018.03.003. 

Griffin P, Michel JJ, Vallejo AN. 2018. Diversity of CD28null T cells in the elderly: A glimpse into biological adaptation of aging. Handbook in Immunosenescence. doi:10.1007/978-3-319-64597-1_87-1. 

Canna SW. The intersections of autoinflammation and cytokine storm. In: Cron RQ and Behrens EM (Eds.), Cytokine Storm Syndromes. Springer Publishing; in press. 

Canna SW. NLRC4-associated Inflammasomopathies section, Chapter on Rare Autoinflammatory Disorders, Textbook of Autoinflammation. Eds. R Laxer, P Hashkes, A Simon. In Press.  

Schulert GS, Canna SW. Convergent Pathways of the Hyperferritinemic Syndromes. International Immunology, 2018 epub PMID 29420734 

Duncan JA & Canna SW. The NLRC4 Inflammasome. Immunological Reviews. 2018; 281(1):115-123. PMID: 29247997 

Moghaddas F, Zeng P, Zhang Y, Schutzle H, Brenner S, Hofmann SR, Berner R, Zhao Y, Lu B, Chen X, Zhang L, Cheng S, Winkler S, Lehmberg K, Canna SW, Czabotar P, Wicks IP, De Nardo D, Hedrich CM, Zeng H, Masters SL. Autoinflammatory mutation in NLRC4 reveals an LRR-LRR oligomerization interface. JACI. 2018 epub May 17. 

Weiss ES, Girard-Guyonvarc’h C, Holzinger D, de Jesus AA, Tariq Z, Picarsic J, Schiffrin EJ, Foell D, Grom AA, Ammann S, Ehl S, Hoshino T, Goldbach-Mansky R, Gabay C, and Canna SW. Dysregulation of Interleukin-18 Diagnostically Distinguishes and Pathogenically Promotes human and murine Macrophage Activation Syndrome. Blood. 2018; 131(13)1442-55. PMID: 29326099 

Aeschlimann FA, Batu ED, Canna SW, Go E, Gul A, Hoffmann P, Leavis, HL, Ozen S, Schwartz DM, Stone DL, Royen-Kerkof AV, Kastner DL, Aksentijevich I, Laxer RM. A20 haploinsufficiency (HA20): Clinical Phenotypes and disease course of patients with a newly recognized NF-kB mediated auto-inflammatory disease. Ann Rheum Dis. 2018; 77(5)728-35. PMID: 29317407 

2017

Moghaddas F, Llamas R, De Nardo D, Martinez-Banaclocha H, Martinez-Garcia JJ, Mesa-del-Castillo P, Baker PJ, Gargallo V, Mensa-Vilaro A, Canna SW, Wicks IP, Pelegrin P, Arostegui JI, Masters SL. A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of Pyrin and distinction to Familial Mediterranean Fever. Ann Rheum Dis. 27 August 2017 [epub ahead of print]

Canna SW, Shi G, Gery I, Sen HN. Chronic, Systemic IL-18 Does Not Promote Macular Degeneration or Choroidal Neovascularization. Invest Ophthalmol Vis Sci 2017; 58:1764-5.

Rood JE, Canna SW, Weaver LK, Tobias JW, Behrens EM. IL-10 distinguishes a unique population of activated, effector-like CD8+ T cells in murine acute liver inflammation. J Leukocyte Biology 2017; 101:1037-44.

Canna SW. The Intersections of Autoinflammation and Cytokine Storm, book chapter in Cytokine Storm Syndromes, Springer Publishing. Cron RQ and Behrens EM, eds. In Press.

Schulert GS, Canna SW. Convergent Pathways of the Hyperferritinemic Syndromes. International Immunology, In Press

Romberg N, Vogel T, Canna SW. NLRC4 Inflammasomopathies. Curr Opin All Clin Immunol 2017 Dec;17(6):398-404.

Tsoukas PA & Canna SW; No Shortcuts: New Findings Reinforce Why Nuance is the Rule in Genetic Autoinflammatory Syndromes. Curr Opin Rheumatol 2017 Sep;29(5):506-515.

Canna SW, Girard C, Malle L, de Jesus AA, Romberg N, Kelsen J, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, Behrens EM. Reply. J Allergy Clin Immunol 2017; 6749:30569.

Griffin P, Michel JJ, Vallejo AN. Diversity of CD28null T cells in the elderly: A glimpse into biological adaptation of aging. Handbook in Immunosenescence. 2017 In press

Lawani M, Fitzpatrick M, Qin S, Martinson J, Michel J, Kessinger C, Leo N, Kingsley L, Greenblatt R, Huang L, Landay A, de Vallejo A, Morris. AM. 2017. Peripheral Blood Monocyte Surface Markers Are Associated With Pulmonary Dysfunction In Hiv Infection. Amer J Respirat Crit Med. 195:A2797.

Shaaban CE, Aizenstein HJ, Jorgensen DR, Meckes NA, Erickson KI, Glynn NW, Mettenburg J, Cohen R, Guralnik J, Newman AB, Ibrahim TS, Laurienti PJ, Vallejo AN, Rosano C. In Vivo Imaging of Venous Side Cerebral Small Vessel Disease in Older Adults: An MRI Method at 7T. Am J Neuroradiol. 2017 Oct;38(10):1923-1928.

Ardalan K, Kelsey C, Torok KS. Predictors of longitudinal quality of life in pediatric localized scleroderma. Arthritis Care Res. 2017 Jul;69(7):1082-1087.

2016

Canna SW, Girard C, Malle L, de Jesus AA, Romberg N, Kelsen J, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, Behrens EM. Life-threatening NLRC4-associated hyperinflammation successfully treated with Interleukin-18 inhibition. J Allergy Clin Immunol. 2016; 6749(16)31352-5.

Michel JJ, Griffin P, Vallejo AN. Functionally diverse NK-like T cells are indicators and predictors of successful aging. Frontiers Immunol. 2016;7:530.

Ferguson I, Griffin P, Yano H, Michel J, Gaffen S, Piganelli J, Dvergsten J, Rosenkranz M, Kietz D, Vallejo A. 2016. Synovitis in juvenile idiopathic arthritis is mediated by TCR-independent CD31-IL17 axis of inflammation. Eur J Immunol. 2016;46(Suppl. 1):542.

Griffin P, Conover C, Bale L, Snyder A, Michel J, Vallejo A. Robust innate immunity underlies protection from acute endotoxicosis in a long-lived mouse model of successful aging. Eur J Immunol. 2016;46(Suppl. 1):870.

Stevens AM, Kanaan SB, Torok KS, Medsger TA, Mayes MD, Reveille, JD, Klein-Gitelman M, Reed AM, Lee T, Li S, Henstorf G, Luu C, Adydelotte T, Nelson JL. Brief Report: HLA-DRB1, DQA1, and DQB1 in juvenile-onset systemic sclerosis. Arthritis and Rheumatology. 2016 Nov;68(11):2772-2777.

Poff S, Li S, Kelsey C, Torok KS. Durometry as an outcome measure in juvenile localized scleroderma. Br J Dermatol. 2016 Jan;174(1):228-30.

Ardoin SP, Robinson A, Torok KS, Van Mater, HA. Chapter 108: Pediatric systemic lupus erythematosus, dermatomyositis, scleroderma, and vasculitis. In: A Reed (Ed.), Kelley and Firestein’s Textbook of Rheumatology (10th ed.) London, England: Sanders; 2016.

2015

Das R, Guan P, Sprague L, Verbist K, Tedrick P, Kurachi M, Levine R, Wherry EJ, Canna SW, Behrens EM, Nichols KE. Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis. Blood 2015;127(13)1666-75.

de Jesus AA*, Canna SW*, Liu Y*, Goldbach-Mansky R. Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling. Annu Rev Immunol 2015;33:823-74.

Canna SW, Nigrovic PA. 21st Century Storm Chasers: Defining Macrophage Activation Syndrome. Arthritis & Rheumatology 2015.

Canna SW, Goldbach-Mansky R. New monogenic autoinflammatory diseases--a clinical overview. Seminars in immunopathology 2015;37:387-94.

Ferguson ID, Griffin P, Yano H, Michel JJ, Dvergsten JA, Gaffen SL, Rosenkranz ME, Kietz DA, Vallejo AN. Interaction between senescent T cells and fibrocyte-like cells through CD31 and IL-17 create a tissue destructive environment in the synovium in juvenile idiopathic arthritis. Arthritis Rheumatol. 2015;67(Suppl. 10).

Ferguson I, Yano H, Griffin P, Michel J, Kietz K, Vallejo AN. A novel subset of fibrocyte-like cells in synovial fluid communicate with CD8 T cells and shape the local inflammatory milieu in juvenile idiopathic arthritis (JIA). J Immunol. 2015;194:121.13

Torok KS, Kurzinski K, Kelsey C, Yabes J, Magee K, Vallejo AN, Medsger T Jr., Feghali-Bostwick CA. Peripheral blood cytokine and chemokine profiles in localized scleroderma. Semin Arthritis Rheum. 2015;45:284-93.

Metti AL, Aizenstein H, Yaffe K, Boudreau RM, Newman A, Launer L, Gianaros PJ, Lopez OL, Saxton J, Ives DG, Kritchevsky S, Vallejo AN, Rosano R. Trajectories of peripheral interleukin-6, structure of the hippocampus, and cognitive impairment over 14 years in older adults. Neurobiol Aging. 2015;36:3038-44.

Mroczkowski HJ, Mihalik SJ, Swigonova Z, Michel JJ, Ralphe JC, Vallejo AN, Vockley, J. VLCAD deficiency leads to an chronic inflammation atypical cytokine and activated monocyte signature. J Inherit Metab Dis. 2015;38(Suppl 1):S200.

Qu Y, Frazer LC, O’Connell CM, Tarantal AF, Andrews Jr CW, O’Connor SL, Russell AN, Sullivan JE, Poston TB, Vallejo AN, Darville T. Comparable genital tract infection, pathology, and immunity in rhesus macaques inoculated with wild-type or plasmid-deficient chlamydia trachomatis serovar D. Infect Immun. 2015;83:4056-67.

Ardalan K, Kelsey C, Torok KS. Predictors of longitudinal quality of life in pediatric localized scleroderma. Arthritis Care and Research. 15-0644. Revision under review. November 2015.

Constantin T, Pain CE, Torok KS, P Höger, Moll M, Nemkova L, Clements P, Foeldvari I. Development of minimum standards of care for juvenile localized Scleroderma. Arthritis Care Res. 13-0636. Revision under review. April 2015.

Ferguson I, Weiser P, Torok, KS. Treatment of recalcitrant childhood localized scleroderma with infliximab. Open Rheumatol J. 2015;9:16-21.

Torok K. Emotional and mental health impact of morphoea demonstrated in adults. Br J Dermatol. 2015;172(5):1188-90.

Torok KS, Kurzinski K, Kelsey C, Yabes J, Magee K, Vallejo AN, Medsger T Jr., Feghali-Bostwick CA. Peripheral blood cytokine and chemokine profiles in localized scleroderma. Semin Arthritis Rheum. 2015;45:284-93.

Poff S, Li S, Kelsey C, Torok KS. Durometry as an outcome measure in juvenile localized scleroderma. J Dermato. 2015