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The Pediatric Institute for Heart Regeneration and Therapeutics (I-HRT) is a research institute within the Department of Pediatrics, University of Pittsburgh School of Medicine, directed by Bernhard Kühn, MD. This institute seeks to improve health by repairing hearts through guided regeneration. The institute strives to develop a scientific basis for heart regeneration through world-class research and training. The institute incorporates basic, translational, and clinical research. I-HRT’s goal is to translate the strategy of stimulating heart muscle cell regeneration into a therapy.
Affiliated Faculty:
Essential Publications
Yao Li, Alberto Bertozzi, Melissa RW Mann and Bernhard Kuhn.
Taylor & Francis Online
August 4, 2023
Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts
Han L, Mich-Basso JD, Li Y, Ammanamanchi N, Xu J, Bargaje A, Liu H, Wu L, Jeong JH, Franks J, Stolz DB, Wu YL, Rajasundaram D, Liu Y, Kühn B
Developmental Cell
2022 Oct 24
Design and rationale of a clinical trial to increase cardiomyocyte division in infants with tetralogy of Fallot
El Khoudary SR, Fabio A, Yester JW, Steinhauser ML, Christopher AB, Gyngard F, Adams PA, Morell VO, Viegas M, DaSilva J, Da Fonseca Da Silva L, Castro-Medina M, McCormick A, Reyes-Múgica M, BarlasM , Liu H, Thomas D, Ammanamanchi A, Sada R, Cuda M, Hartigan E, Groscost DK, Kühn B
International Journal of Cardiology
2021 Sep 15
Jessie W. Yester, Honghai Liu, Frank Gyngard, Niyatie Ammanamanchi, Katherine C. Little, Dawn Thomas, Mara L.G. Sullivan, Sean Lal, Matthew L. Steinhauser, and Bernhard Kühn. Nature Protocols. Feb 24, 2021.
Cardiac Regeneration: Methods and Protocols
(ed. Kühn B, Poss K).
Lamin B2 levels regulate polyploidization of cardiomyocyte nuclei and myocardial regeneration.
Han L, Choudhury S, Mich-Basso JD, Ammanamanchi N, Ganapathy G, Suresh S, Khaladkar M, Singh J, Maehr R, Zuppo DA, Kim J, Eberwine JH, Wyman SK, Wu Y & Kühn B.
Dev. Cell 2020; 6;53(1):42-59. PMID: 32109383, PMCID: PMC7346764.
Contact
Pediatric Institute for Heart Regeneration and Therapeutics
John G. Rangos Sr. Research Center, 8th Floor
UPMC Children’s Hospital of Pittsburgh
4401 Penn Avenue
Pittsburgh, PA 15224
Administrative Manager: Maureen Fortunato
Administrative Coordinator: Kim Birsic
Events
June 21, 2023, 4 - 5PM
Mustafa Khoka, MD
Professor of Pediatrics (Critical Care Medicine, Genetics)
Yale New Haven Children’s Hospital
October 23 - 24, 2023
Martina Brueckner, MD
Professor of Pediatrics (Cardiology)
Yale New Haven Children’s Hospital
November 6 - 7, 2023
Jonathan G. Seidman, PhD
Henrietta B. and Frederick H, Bugher Foundation
Professor of Genetics, Harvard Medical School,
Cardiovascular Division of Brigham and Women’s Hospital
February 19 - 20