Selected Publications

2020

Thakur N, Lovinsky-Desir S, Bime C, Wisnivesky JP, Celedón JC. Health Equality and Diversity Committee of the American Thoracic Society. The Structural and Social Determinants of the Racial/Ethnic Disparities in the U.S. COVID-19 Pandemic: What's Our Role? Am J Respir Crit Care Med. 2020 Jul 17. Online ahead of print. 

Alcorn JF. IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary Infection. Front Immunol. 2020 Jun 9;11:1160. eCollection 2020.

Tobin JM, Nickolich KL, Ramanan K, Pilewski MJ, Lamens KD, Alcorn JF, Robinson KM. Influenza Suppresses Neutrophil Recruitment to the Lung and Exacerbates Secondary Invasive Pulmonary Aspergillosis. J Immunol. 2020 Jul 15;205(2):480-488. 

Landeo-Gutierrez J, Han YY, Forno E, Rosser FJ, Acosta-Pérez E, Canino G, Celedón JC. Risk factors for  atopic and nonatopic asthma in Puerto Rican children. Pediatr Pulmonol. 2020 Jun 27. Online ahead of print. 

Yang G, Han YY, Forno E, Yan Q, Rosser F, Chen W, Celedón JC. Glycated Hemoglobin A1c, Lung Function, and Hospitalizations Among Adults with Asthma. J Allergy Clin Immunol Pract. 2020 Jun 20:S2213-2198(20)30616-4.

Kim S, Forno E, Zhang R, Park HJ, Xu Z, Yan Q, Boutaoui N, Acosta-Pérez E, Canino G, Chen W, Celedón JC. Expression quantitative trait methylation analysis reveals methylomic associations with gene expression in childhood asthma. Chest. 2020 Jun 19:S0012-3692(20)31716-5. 

Stevens EL, Rosser F, Han YY, Forno E, Acosta-Pérez E, Canino G, Celedón JC. Traffic-related Air Pollution, Dust Mite Allergen, and Childhood Asthma in Puerto Ricans. Am J Respir Crit Care Med. 2020 Jul 1;202(1):144-146. 

Landeo-Gutierrez J, Marsland AL, Acosta-Pérez E, Canino G, Celedón JC. Exposure to violence, chronic stress, asthma, and bronchodilator response in Puerto Rican children. Ann Allergy Asthma Immunol. 2020 Jun;124(6):626-627.e1. 

Forno E, Zhang R, Jiang Y, Kim S, Yan Q, Ren Z, Han YY, Boutaoui N, Rosser F, Weeks DE, Acosta-Pérez E, Colón-Semidey A, Alvarez M, Canino G, Chen W, Celedón JC. Transcriptome-wide and differential expression network analyses of childhood asthma in nasal epithelium. J Allergy Clin Immunol. 2020 Feb 20:S0091-6749(20)30197-4. Online ahead of print. 

Han YY, Forno E, Rosser F, Celedón JC. Serum folate metabolites, asthma, and lung function in a nationwide US study. J Allergy Clin Immunol. 2020 Jul;146(1):220-222.e8. 

Kim S, Forno E, Yan Q, Jiang Y, Zhang R, Boutaoui N, Acosta-Pérez E, Canino G, Chen W, Celedón JC. SNPs identified by GWAS affect asthma risk through DNA methylation and expression of cis-genes in airway epithelium. Eur Respir J. 2020 Apr 3;55(4):1902079. 

Han YY, Rosser F, Forno E, Celedón JC. Electronic vapor products, marijuana use, smoking, and asthma in US adolescents. J Allergy Clin Immunol. 2020 Mar;145(3):1025-1028.e6.

Rosser F, Forno E, Kurland KS, Han YY, Mair C, Acosta-Pérez E, Canino G, Celedón JC. Annual SO2 exposure, asthma, atopy, and lung function in Puerto Rican children. Pediatr Pulmonol. 2020 Feb;55(2):330-337. 

Landeo-Gutierrez J, Forno E, Miller GE, Celedón JC. Exposure to Violence, Psychosocial Stress, and Asthma. Am J Respir Crit Care Med. 2020 Apr 15;201(8):917-922. 

Han YY, Jerschow E, Forno E, Hua S, Mossavar-Rahmani Y, Perreira KM, Sotres-Alvarez D, Afshar M, Punjabi NM, Thyagarajan B, Shivappa N, Hébert JR, Kaplan RC, Celedón JC. Dietary Patterns, Asthma, and Lung Function in the Hispanic Community Health Study/Study of Latinos. Ann Am Thorac Soc. 2020 Mar;17(3):293-301. 

Han YY, Forno E, Celedón JC. Sex Steroid Hormones and Asthma in a Nationwide Study of U.S. Adults. Am J Respir Crit Care Med. 2020 Jan 15;201(2):158-166.

2019

Yang G, Han YY, Sun T, Li L, Rosser F, Forno E, Patel SR, Chen W, Celedón JC. Sleep Duration, Current Asthma, and Lung Function in a Nationwide Study of U.S. Adults. Am J Respir Crit Care Med. 2019 Oct 1;200(7):926-929. 

Boutaoui N, Puranik S, Zhang R, Wang T, Hui DH, Brehm J, Forno E, Chen W, Celedón JC. Epigenome-wide effects of vitamin D on asthma bronchial epithelial cells. Epigenetics. 2019 Sep;14(9):844-849. 

Yan Q, Liu N, Forno E, Canino G, Celedón JC, Chen W. An integrative association method for omics data based on a modified Fisher's method with application to childhood asthma. PLoS Genet. 2019 May 7;15(5):e1008142. eCollection 2019 May.

Stevens EL, Rosser F, Forno E, Peden D, Celedón JC. Can the effects of outdoor air pollution on asthma be mitigated? J Allergy Clin Immunol. 2019 Jun;143(6):2016-2018.e1. 

Forno E, Celedón JC. Epigenomics and Transcriptomics in the Prediction and Diagnosis of Childhood Asthma: Are We There Yet? Front Pediatr. 2019 Apr 2;7:115. eCollection 2019. 

Gopal R, Mendy A, Marinelli MA, Richwalls LJ, Seger PJ, Patel S, McHugh KJ, Rich HE, Grousd JA, Forno E, Alcorn JF. Peroxisome Proliferator-Activated Receptor Gamma (PPAR) Suppresses Inflammation and Bacterial Clearance during Influenza-Bacterial Super-Infection. Viruses. 2019 Jun 1;11(6):505. 

Abood RN, McHugh KJ, Rich HE, Ortiz MA, Tobin JM, Ramanan K, Robinson KM, Bomberger JM, Kolls JK, Manni ML, Pociask DA, Alcorn JF. IL-22-binding protein exacerbates influenza, bacterial super-infection. Mucosal Immunol. 2019 Sep;12(5):1231-1243. 

Rich HE, McCourt CC, Zheng WQ, McHugh KJ, Robinson KM, Wang J, Alcorn JF. Interferon Lambda Inhibits Bacterial Uptake during Influenza Superinfection. Infect Immun. 2019 Apr 23;87(5):e00114-19. 

Jiang Y, Gruzieva O, Wang T, Forno E, Boutaoui N, Sun T, Merid SK, Acosta-Pérez E, Kull I, Canino G, Antó JM, Bousquet J, Melén E, Chen W, Celedón JC. Transcriptomics of atopy and atopic asthma in white blood cells from children and adolescents. Eur Respir J. 2019 May 18;53(5):1900102. 

Han YY, Forno E, Celedón JC. Health risk behaviors, violence exposure, and current asthma among adolescents in the United States. Pediatr Pulmonol. 2019 Mar;54(3):237-244. 

Forno E, Wang T, Qi C, Yan Q, Xu CJ, Boutaoui N, Han YY, Weeks DE, Jiang Y, Rosser F, Vonk JM, Brouwer S, Acosta-Perez E, Colón-Semidey A, Alvarez M, Canino G, Koppelman GH, Chen W, Celedón JC. DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study. Lancet Respir Med. 2019 Apr;7(4):336-346. PMID: 30584054

Han YY, Forno E, Celedón JC. Anxiety and noneosinophilic asthma among adults in the United States. J Allergy Clin Immunol Pract. 2019 Apr;7(4):1367-1369.e1. 

2018 

Robinson KM, Ramanan K, Clay ME, McHugh KJ, Rich HE, and JF Alcorn. Novel protective mechanism for interleukin – 33 at the mucosal barrier during influenza-associacted bacterial superinfection. Mucosal Immunol 11(1):199-208, 2018.

Szentpetery SE, Han YY, Brehm JM, Acosta-Pérez E, Forno E, Boutaoui N, Canino G, Alcorn JF, Celedón JC. Vitamin D insufficiency, plasma cytokines, and severe asthma exacerbations in school-aged children. J Allergy Clin Immunol Pract 6(1):289-291, 2018. 

Shinde A, Luo J, Bharathi SS, Shi H, Beck ME, McHugh KJ, Alcorn JF, Wang J, Goetzman ES. Increased mortality from influenza infection in long-chain acyl-CoA dehydrogenase knockout mice. Biochem Biophys Res Commun 497(2):700-704, 2018. 

Robinson KM, Ramanan K, Clay ME, McHugh KJ, Pilewski MJ, Nickolich KL, Corey C, Shiva S, Wang J, and JF Alcorn. The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice. JCI Insight. 2018 Apr 5;3(7). pii: 97470. 

Gopal R, Lee B, McHugh KJ, Rich HE, Ramanan K, Mandalapu S, Clay ME, Seger PJ, Enelow RI, Manni ML, Robinson KM, Rangel-Moreno J, Alcorn JF. STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection. Front Immunol. 2018 Sep 25;9:2151. eCollection 2018.

Elsegeiny W, Zheng M, Eddens T, Gallo RL, Dai G, Trevejo-Nunez G, Castillo P, Kracinovsky K, Cleveland H, Horne W, Franks J, Pociask D, Pilarski M, Alcorn JF, Chen K, and JK Kolls. Murine models of Pneumocystis infection recapitulate human primary immune disorders. JCI Insight. 2018 Jun 21;3(12). pii: 91894. 

Rich HE and JF Alcorn. IL-17 Strikes a Chord in Chronic Obstructive Pulmonary Disease Exacerbation. Am J Respir Cell Mol Biol 58(6):669-670, 2018. 

Rosser F, Han YY, Forno E, Celedón JC. Urinary polycyclic aromatic hydrocarbons and allergic sensitization in a nationwide study of children and adults in the United States. J Allergy Clin Immunol. 2018 Nov;142(5):1641-1643.e6. 

Han YY, Forno E, Boutaoui N, Canino G, Celedón JC. Vitamin D insufficiency, TH2 cytokines, and allergy markers in Puerto Rican children with asthma. Ann Allergy Asthma Immunol. 2018 Oct;121(4):497-498.e1. 

Han YY, Forno E, Shivappa N, Wirth MD, Hébert JR, Celedón JC. The Dietary Inflammatory Index and Current Wheeze Among Children and Adults in the United States. J Allergy Clin Immunol Pract. 2018 May-Jun;6(3):834-841.e2. 

2017 

Pociask DA, Robinson KM, Chen K, McHugh KJ, Clay ME, Huang GT, Benos PV, Janssen-Heininger YMW, Kolls JK, Anathy V, and JF Alcorn. Epigenetic and Transcriptomic Regulation of Lung Repair During Recovery from Influenza Infection. Am J Pathol 187(4):851-863, 2017. 

Treerat P, Prince O, Cruz-Lagunas A, Muñoz-Torrico M, Salazar-Lezama MA, Selman M, Fallert-Junecko B, Reinhardt T, Alcorn JF, Kaushal D, Zuñiga J, Rangel-Moreno J, Kolls JK, and SA Khader. Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection. Mucosal Immunol 10(4):1069-1081, 2017. 

Manni ML, Mandalapu S, Salmeron A, Lora JM, Kolls JK, and JF Alcorn. Bromodomain and Extra-Terminal Protein Inhibition Attenuates Neutrophil-dominant Allergic Airway Disease. Sci Rep 2017 Feb 24;7:43139. 

Zhang H, Luo J, Alcorn JF, Chen K, Fan S, Pilewski J, Liu A, Chen W, Kolls JK, and J Wang. AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality. J Immunol 198(11):4383-4393, 2017. 

Forno E, Wang T, Yan Q, Brehm J, Acosta-Perez E, Colon-Semidey A, Alvarez M, Boutaoui N, Cloutier MM, Alcorn JF, Canino G, Chen W, Celedón JC. A Multi-omics Approach to Identify Genes Associated with Childhood Asthma Risk and Morbidity. Am J Respir Cell Mol Biol 57(4):439-447, 2017.

Medsker BH, Forno E, Han YY, Acosta-Pérez E, Colón-Semidey A, Alvarez M, Alcorn JF, Canino GJ, Celedón JC. Cockroach allergen exposure and plasma cytokines among children in a tropical environment. Ann Allergy Asthma Immunol. 2017 Jul;119(1):65-70.e3. 

Lee B, Gopal R, Manni ML, McHugh KJ, Mandalapu S, Robinson KM, and JF Alcorn. Signal transducer and activator of transcription 1 is Required for Suppression of Type 17 Immunity During Influenza, Bacterial Super-infection. ImmunoHorizons 1 (6): 81-91, 2017. 

Cole KS, Martin JM, Horne WT, Lin CJ, Nowalk MP, Alcorn JF, and RK Zimmerman. Differential Gene Expression Elicited by Children in response to the 2015-16 Live Attenuated versus Inactivated Influenza Vaccine. Vaccine 35:6893-6897. 2017. 

Celedón JC, Burchard EG, Schraufnagel D, Castillo-Salgado C, Schenker M, Balmes J, Neptune E, Cummings KJ, Holguin F, Riekert KA, Wisnivesky JP, Garcia JGN, Roman J, Kittles R, Ortega VE, Redline S, Mathias R, Thomas A, Samet J, Ford JG; American Thoracic Society and the National Heart, Lung, and Blood Institute. An American Thoracic Society/National Heart, Lung, and Blood Institute Workshop report: addressing respiratory health equality in the United States. Ann Am Thorac Soc. 2017 May;14(5):814-826. 

Chen W, Wang T, Pino-Yanes M, Forno E, Liang L, Yan Q, Hu D, Weeks D, Baccarelli A, Acosta-Perez E, Eng C, Han YY, Boutaoui N, Laprise C, Davies G, Hopkin J, Moffatt M, Cookson W, Canino G, Burchard E, Celedón JC. An epigenome-wide association study of total serum immunoglobulin E in Hispanic children. J Allergy Clin Immunol. 2017;140(2):571-577. 

Forno E, Weiner D, Mullen J, Sawicki G, Kurland G, Han Y, Cloutier M, Canino G, Weiss S, Litonjua A, Celedón JC. Obesity and airway dysanapsis in children with and without asthma. Am J Respir Crit Care Med. 2017;195(3):314-323. 

Forno E, Sordillo J, Brehm J, Chen W, Benos T, Yan Q, Avila L, Soto-Quiros M, Cloutier M, Colón-Semidey A, Alvarez M, Acosta-Pérez E, Weiss S, Litonjua A, Canino G, Celedón JC. Genome-wide interaction study of dust mite allergen on lung function in children with allergy. J Allergy Clin Immunol. 2017 Oct;140(4):996-1003.e7. 

Forno E, Wang T, Yan Q, Brehm J, Acosta-Perez E, Colon-Semidey A, Alvarez M, Boutaoui N, Cloutier MM, Alcorn JF, Canino G, Chen W, Celedón JC. A multi-omics approach to identify genes associated with childhood asthma risk and morbidity. Am J Respir Cell Mol Biol. 2017; 57(4):439-447.  

Han YY, Forno E, Celedón JC. Vitamin D insufficiency and asthma in a U.S. nationwide study. J Allergy Clin Immunol Pract. 2017; 5(3):790-796. 

Han YY, Badellino HA, Forno E, Celedón JC. Rural residence, farming environment, and allergic diseases in Argentinean adolescents. Pediatr Pulmonol. 2017; 52(1):21-28.  

Han YY, Forno E, Badellino HA, Celedón JC. Antibiotic use in early life, rural residence, and allergic diseases in Argentinean children. J Allergy Clin Immunol Pract. 2017; 5(4):1112-1118. 

Medsker BH, Brew BK, Forno E, Olsson H, Lundholm C, Han YY, Acosta-Pérez E, Canino GJ, Almqvist C, Celedón JC. Maternal depressive symptoms, maternal asthma, and asthma in school-aged children. Ann Allergy Asthma Immunol. 2017; 118(1):55-60. 

Medsker BH, Forno E, Han YY, Acosta-Pérez E, Colón-Semidey A, Alvarez M, Alcorn JF, Canino GJ, Celedón JC. Cockroach allergen exposure and plasma cytokines among children in a tropical environment. Ann Allergy Asthma Immunol. 2017; 119(1):65-70 

Puranik S, Forno E, Bush A, Celedón JC. Predicting severe asthma exacerbations in children. Am J Respir Crit Care Med. 2017;195(7):854-859. 

Yan Q, Brehm J, Pino-Yanes M, Forno E, Lin J, Oh SS, Acosta-Perez E, Laurie CC, Cloutier MM, Raby BA, Stilp AM, Sofer T, Hu D, Huntsman S, Eng CS, Conomos MP, Rastogi D, Rice K, Canino G, Chen W, Barr RG, Burchard EG, Celedón JC. A meta-analysis of genome-wide association studies of asthma in Puerto Ricans. Eur Respir J. 2017; 49(5).  

Forno E, Celedón JC. The effect of obesity, weight gain, and weight loss on asthma inception and control. Curr Opin Allergy Clin Immunol. 2017; 17(2):123-130. 

Szentpetery SE, Han YY, Brehm JM, Acosta-Perez E, Forno E, Boutaoui N, Canino G, Alcorn JF, Celedón JC. Vitamin D insufficiency, plasma cytokines, and severe asthma exacerbations in school-aged children. J Allergy Clin Immunol Pract. 2017 Aug 25. pii: S2213-2198(17)30544-5. 

Chen W, Wang T, Pino-Yanes M, Forno E, Liang L, Yan Q, Hu D, Weeks DE, Baccarelli A, Acosta-Perez E, Eng C, Han YY, Boutaoui N, Laprise C, Davies GA, Hopkin JM, Moffatt MF, Cookson WOCM, Canino G, Burchard EG, Celedón JC. An epigenome-wide association study of total serum IgE in Hispanic children. J Allergy Clin Immunol. 2017 Aug;140(2):571-577. 

2016 

Blatter J, Brehm J, Sordillo J, Forno E, Boutaoui N, Acosta-Pérez E, Alvarez M, Colón-Semidey A, Weiss ST, Litonjua A, Canino G, Celedón JC. Folate deficiency, atopy, and severe asthma exacerbations in Puerto Rican children. Annals Am Thorac Soc. 2016;13(2):223-30. 

Castro-Rodríguez JA, Forno E, Rodríguez-Martínez C, Celedón JC. Risk and protective factors for childhood asthma: What is the evidence? J Allergy Clin Immunol Pract. 2016;4(6):1111-22. 

de la Hoz R, Jeon Y, Miller G, Wisnivesky J, Celedón JC. Post-traumatic stress disorder, bronchodilator response, and incident asthma in World Trade Center rescue and recovery workers. Am J Respir Crit Care Med. 2016;194(11):1383-91. 

Sloane D, Govindarajulu U, Harrow-Mortelliti J, Barry W, Hsu FI, Hong D, Laidlaw T, Palis R, Legere H, Bunyavanich S, Breslow R, Wesemann D, Barrett N, Brennan P, Chong HJ, Liu A, Fernandez J, Fanning L, Kyin T, Cahill K, Bankova L, Lynch A, Berlin S, Campos S, Fuchs C. Mayer R, Matulonis U, Castells M. Safety, costs and efficacy of rapid drug desensitizations to chemotherapy and monoclonal antibodies. J Allergy Clin Immunol Pract. 2016 May-Jun;4(3):497-504. 

Han YY, Forno E, Marsland A, Miller GE, Celedón JC. Depression, asthma, and bronchodilator response in a nationwide study of U.S. adults. J Allergy Clin Immunol Pract. 2016;4(1):68-73. 

Han YY, Forno E, Gogna M, Celedón JC. Obesity and rhinitis in a nation-wide study of children and adults in the United States. J Allergy Clin Immunol. 2016;137(5):1460-5. 

Rosas-Salazar C, Han YY, Brehm J, Forno E, Acosta-Pérez E, Cloutier M, Alvarez M, Colón-Semidey A, Canino G, Celedón JC. Gun violence, African ancestry, and asthma: A case-control study in Puerto Rican children. Chest. 2016;149(6):1436-44. 

Rosser F, Forno E, Brehm J, Han YY, Boutaoui N, Colón-Semidey A, Alvarez M, Acosta-Pérez E, Kurland K, Alcorn J, Canino G, Celedón JC. Proximity to a major road and plasma cytokines in school-aged children. Pediatr Allergy Immunol Pulmonol. 2016;29(3):111-7. 

Szentpetery SE, Forno E, Canino G, Celedón JC. Asthma in Puerto Ricans: Lessons from a high-risk population. J Allergy Clin Immunol. 2016; 138(6):1556-1558.