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Brian T. Campfield, MD
- Assistant Professor of Pediatrics
- Scholar, Richard King Mellon Foundation Institute for Pediatric Research
Brian T. Campfield joined the division as Assistant Professor of Pediatrics in 2014, providing subspecialty patient care and conducting research investigating the role of follistatin-like protein 1 (FSTL-1) in host defense and homeostasis in the lung, with a focus on innate immune responses and their impact on adaptive immunity. His lab employs multiple approaches including in vitro and in vivo animal models of sterile inflammation as well as bacterial pneumonia and viral infection. His lab is supported by funding from the NIH, the University of Pittsburgh School of Medicine and UPMC Children’s Hospital of Pittsburgh.
Campfield is a graduate of the University of Virginia and the University of Pittsburgh School of Medicine. He completed his Pediatrics residency and Pediatric Infectious Diseases fellowship at the Children’s Hospital of Pittsburgh of UPMC/University of Pittsburgh.
As a clinical subspecialist in Pediatric Infectious Diseases, Campfield provides care for inpatients and outpatients with a wide variety of complex infectious disease issues. His areas of interest include diagnosis and care of infectious complications in immunocompromised patients, including primary immunodeficiency and organ transplant recipients, patients with critical illnesses due to infectious diseases as well as children with Lyme disease.
Education & Training
- BA, Biology, University of Virginia, 2002
- MD, University of Pittsburgh School of Medicine, 2006
Selected Publications
Campfield BT, Nolder CL, Davis A, Hirsch R, Nowalk AJ. The DBA/1 Strain is a Novel Mouse Model for Experimental Borrelia burgdorferi Infection. Clin Vaccine Immunol. 2012 Oct. PMID 22855391. PMCID PMC3485876.
Campfield BT, Nolder CL, Davis A, Bushnell D, Marinov A, Hirsch R, Nowalk AJ. Follistatin-like Protein 1 is a Critical Mediator of Experimental Lyme Arthritis and the Humoral Response to Borrelia burgdorferi Infection. Microb Pathog 2014. PMID 24768929. PMCID: PMC4899828.
Eddens T, Campfield BT, Serody K, Manni ML, Horne W, Elsegeiny W, McHugh KJ, Pociask D, Chen K, Zheng M, Alcorn JF, Wenzel S, Kolls JK A Novel CD4+ T-cell Dependent Murine Model of Pneumocystis Driven Asthma-like Pathology. Am J Respir Crit Care Med. 2016 Oct 1 PMID: 27007260 PMCID: PMC5074654
Chen K, Campfield BT, Wenzel SE, McAleer JP, Kreindler JL, Kurland G, Gopal R, Wang T, Chen W, Eddens T, Quinn K, Myerburg MM, Horne WT, Lora JM, Albrecht BK, Pilewski JM, Kolls JK. Antiinflammatory Effects of Bromodomain and Extraterminal Domain Inhibition in Cystic Fribrosis Lung Inflammation. JCI Insight 2016 Jul 21; 1(11). PMID: 27517095. PMCID: PMC4978187. DOI: 10.1172/jci.insight.87168
Campfield BT*, Eddens T, Henkel M, Majewski M, Horne W, Chaly Y, Gaffen SL, Hirsch R, Kolls JK. Follistatin-like protein 1 modulates IL-17 signaling via IL-17RC regulation in stromal cells. Immunol Cell Biol. 2017 Sep;95(8):656-665. PMID: 28377613 PMCID: PMC5609702 DOI 10.1038/icb.2017.26.
Eddens T, Kaplan DJ, Anderson AJM, Nowalk AJ, Campfield BT*. Insights from the Geographic Spread of the Lyme Disease Epidemic. Clin Infect Dis. 2019 Jan 18;68(3):426-434. 16 doi:10.1093/cid/ciy510 PMID: 29920580 PMCID: PMC6336907
Henkel M, Partyka J, Gregory AD, Forno E, Cho MH, Eddens T, Tout AR, Salamacha N, Horne W, Rao KS, Wu Y, Alcorn JF, Kostka D, Hirsch R, Celedón JC, Kolls JK, Campfield BT*. Follistatin-like 1 Attenuation Causes Spontaneous Smoke-Resistant Pulmonary Emphysema. Am J Respir Crit Care Med. 2020 Apr 15;201(8):934-945. doi: 10.1164/rccm.201905-1973OC. PubMed PMID: 31834999.
Henkel M, Dutta JA, Partyka J, Eddens T, Hirsch R, Kolls JK, Campfield BT*. Regulation of Pulmonary Bacterial Immunity by Follistatin-like 1. Infect Immun. 2020 Dec 15. IAI.00298-20. Doi: 10.1128/IAI.00298-20 PMID: 33077624.
Eddens T, Wolfe R, Nowalk A, Forno E, Campfield B*. Association of Trimethoprim-sulfamethoxazole with Improved Lung Function in Pediatric Asthma. Ann Allergy Asthma Immunol. 2021 Jan 16: S1801-1206(21)00021-1. Doi: 10.1016/j.anai.2021.01.013. PMID 33465454
Gaietto K, Freeman MC, DiCicco LA, Rauenswinter S, Squire JR, Aldewereld Z, Iagnemma J, Campfield BT, Wolfson D, Kazmerski TM, Forno E. Asthma as a Risk Factor for Hospitalization in Children with COVID-19: A Nested Case-Control Study. Pediatr Allergy Immunol. 2021 Nov 14. Doi10/1111/pai.13696. PMID: 34775650
Sugitani N, Henkel M, Partyka J, Applegate A, Kemp F, Byersdorfer CA, Eddens T, Campfield BT*. Nuclear Receptor 4A1 is Critical for Neutrophil-Dependent Pulmonary Immunity to Klebsiella pneumoniae Infection. Front Immunol. 2025;16:1558252. doi: 10.3389/fimmu.2025.1558252. eCollection 2025 March 5. PMID: 40114913; PMCID: PMC11922696.
Dewicki A, Henkel M, Sugitani N, Applegate A, Campfield BT*. Performance of Time-Lapsed Turbidimetry and Agar Plating as Bacterial Quantification Methods. Microbiol Spectr. 2026 Feb 3;14(2):e0180725. Doi: 10.1128/spectrum.0187-25. PMID: 41451991; PMCID: PMC12889079.
Academic and Research Interests
- Host-Pathogen interactions in the lung
- The role of Follistatin-like protein 1 in lung inflammation