The MEASURE Study (Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children) is a research study designed to help doctors and families better understand how to treat common childhood infections.
Ear infections and sinus infections are among the most common reasons children receive antibiotics. However, not every child may benefit from antibiotics, and different antibiotics may work better for some children than others. The MEASURE Study is comparing commonly used treatment approaches to learn which treatments work best, which children benefit most from antibiotics, and how treatment affects symptoms and recovery.
The study includes children 6 months to under 12 years of age who have been diagnosed with either an acute ear infection (AOM) or acute sinusitis (AS). Children who meet the study requirements will be randomly assigned to a treatment group.
Children may receive:
- Placebo (similar to watchful waiting)
- Amoxicillin
- Amoxicillin-clavulanate (Augmentin)
The study is blinded, meaning families and study team members will not know which treatment a child receives during the study. Families will be asked to provide information about their child's symptoms and recovery through brief daily diaries and participate in scheduled study follow-up.
The MEASURE Study is patient-centered, meaning families and caregivers helped shape the study to address questions that matter to them.
Why is this study important?
By comparing these treatment approaches, researchers hope to provide better information about when antibiotics are helpful for children with ear and sinus infections. The results may help healthcare providers and families make more informed treatment decisions and support the right treatment for the right child.
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