Pitt Pediatrics congratulates the Pandey Lab led by Udai Pandey, PhD, for their recent publication in Nucleic Acids Research titled “Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo” and R01 grant award for their project “Identifying the molecular mechanisms of GEMIN5 mutations in a novel cerebellar ataxia syndrome.”
The lab’s recent publication shows research that may explain the association between ALS-linked FUS (Fused in Sarcoma gene) mutations and the Drosha-dependent miRNA regulatory circuit, as well as a useful perspective on potential ALS treatment via microRNAs.
The lab’s R01 award was granted on the basis to understand the molecular base of a rare neurodevelopmental disorder. They plan on doing this by conducting functional analysis of mutant GEMIN5 patient neurons, examining if the protein variants cause mitochondrial dysfunctions in vivo and iPSC neurons, and investigating the mechanisms of the protein mutations in mouse models. This R01 was done in part with Deepa Rajan, MD, FAAP, who was a co-investigator on this grant.
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